G
Glenn Dranoff
Researcher at Harvard University
Publications - 8
Citations - 3587
Glenn Dranoff is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Cancer. The author has an hindex of 6, co-authored 8 publications receiving 3045 citations. Previous affiliations of Glenn Dranoff include Brigham and Women's Hospital.
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Journal ArticleDOI
Cancer immunotherapy comes of age
TL;DR: In the context of advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, these successes suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients.
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Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.
Baochun Zhang,Sven Kracker,Tomoharu Yasuda,Stefano Casola,Stefano Casola,Matthew Vanneman,Cornelia Hömig-Hölzel,Zhe Wang,Emmanuel Derudder,Shuang Li,Tirtha Chakraborty,Shane E. Cotter,Shohei Koyama,Treeve Currie,Gordon J. Freeman,Jeffery L. Kutok,Scott J. Rodig,Glenn Dranoff,Klaus Rajewsky,Klaus Rajewsky +19 more
TL;DR: A central role for LMP1 in the surveillance and transformation of EBV-infected B cells in vivo is indicated, a preclinical model for B cell lymphomagenesis in immunosuppressed patients is established, and a new therapeutic approach is validated.
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IAP inhibitors enhance co-stimulation to promote tumor immunity
Michael Dougan,Stephanie K. Dougan,Joanna Slisz,Brant Firestone,Matthew Vanneman,Dobrin Draganov,Girija Goyal,Weibo Li,Weibo Li,Donna Neuberg,Richard S. Blumberg,Nir Hacohen,Nir Hacohen,Dale Porter,Leigh Zawel,Glenn Dranoff +15 more
TL;DR: It is found that IAP antagonists can augment human and mouse T cell responses to physiologically relevant stimuli and suggest that targeting IAPs using small molecule antagonists may be a strategy for developing novel immunomodulating therapies against cancer.
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A dual role for the immune response in a mouse model of inflammation-associated lung cancer
Michael Dougan,Danan Li,Donna Neuberg,Martin C. Mihm,Paul B. Googe,Kwok-Kin Wong,Glenn Dranoff +6 more
TL;DR: A model whereby cytokine deficiency leads to oncogenic inflammation that combines with defective antitumor immunity to promote lung tumor formation is suggested, representing a unique system for studying the role of the immune system in lung tumor development.
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Active Immunotherapy Induces Antibody Responses That Target Tumor Angiogenesis
Jonathan D. Schoenfeld,Masahisa Jinushi,Yukoh Nakazaki,Daniel C. Wiener,Joosang Park,Robert J. Soiffer,Donna Neuberg,Martin C. Mihm,F. Stephen Hodi,Glenn Dranoff +9 more
TL;DR: Together, these results delineate an immunotherapy-induced host response that broadly targets the angiogenic network in the tumor microenvironment.