Goichi Miyoshi

TL;DR: Using genetic engineering in mice, approximately 20 Cre and inducible CreER knockin driver lines that reliably target major classes and lineages of GABAergic neurons are generated, thereby enabling a systematic and comprehensive analysis from cell fate specification, migration, and connectivity, to their functions in network dynamics and behavior.

TL;DR: By combining an inducible genetic fate mapping strategy with electrophysiological analysis, this work systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE), and determined the spatial and temporal origins of the vast majority of cortical interneuron subtypes.

TL;DR: It is observed that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

TL;DR: This work employs a conditional loss-of-function approach to demonstrate that the transcription factor Nkx2-1 is required for the proper specification of specific interneuron subtypes and reveals a causal link between the embryonic genetic specification by Nkkx1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system.

TL;DR: It is found that interneuron subtypes are born with a characteristic temporal pattern and the characterization of interneurons from the Nkx6-2 lineage is extended through the application of electrophysiological methods.