G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Oxford genome screen for asthma-associated traits.
TL;DR: The ascertainment, phenotypicData, and genotypic data made available for Genetic Analysis Workshop 12 are described, which describes the ascertainment of quantitative traits underlying asthma and their linkage to the genome.
Posted ContentDOI
Population and individual effects of non-coding variants inform genetic risk factors
Mauro Pala,Zachary Zappala,Mara Marongiu,Xin Li,Joe R. Davis,Roberto Cusano,Francesca Crobu,Kimberly R. Kukurba,Frederic Reiner,Riccardo Berutti,Maria Grazia Piras,Antonella Mulas,Magdalena Zoledziewska,Michele Marongiu,Fabio Busonero,Andrea Maschio,Maristella Steri,Carlo Sidore,Serena Sanna,Edoardo Fiorillo,Alexis Battle,John Novembre,Chris Jones,Andrea Angius,Gonçalo R. Abecasis,David Schlessinger,Francesco Cucca,Stephen B. Montgomery +27 more
TL;DR: Using whole genomes and peripheral white blood cell transcriptomes from 624 Sardinian individuals, Sardinian eQTLs were identified at genes involved in malarial resistance and multiple sclerosis, reflecting the long-term epidemiological history of the island’s population.
Posted ContentDOI
Imputation aware tag SNP selection to improve power for multi-ethnic association studies
Genevieve L. Wojcik,Christian Fuchsberger,Daniel Taliun,Ryan P. Welch,Alicia R. Martin,Suyash Shringarpure,Christopher S. Carlson,Gonçalo R. Abecasis,Hyun Min Kang,Michael Boehnke,Carlos Bustamante,Christopher R. Gignoux,Eimear E. Kenny +12 more
TL;DR: A novel pipeline to select tag SNPs using the 26 population reference panel from Phase of the 1000 Genomes Project is developed and the unified framework presented will enable investigators to make informed decisions for the design of new arrays, and help empower the next phase of rare variant association for global health.
Posted ContentDOI
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution
Anne E. Justice,Tugce Karaderi,Heather M. Highland,Kristin L. Young,Mariaelisa Graff,Yingchang Lu,Valérie Turcot,Paul L. Auer,Rebecca S. Fine,Xiuqing Guo,Claudia Schurmann,Adelheid Lempradl,Eirini Marouli,Anubha Mahajan,Thomas W. Winkler,Adam E. Locke,Carolina Medina-Gomez,Tõnu Esko,Sailaja Vedantam,Ayush Giri,Ken Sin Lo,Tamuno Alfred,Poorva Mudgal,Maggie C.Y. Ng,Nancy C Heard-Costa,Mary F. Feitosa,Alisa K. Manning,Sara M. Willems,Suthesh Sivapalaratnam,Gonçalo R. Abecasis,Dewan S. Alam,Matthew A. Allison,Philippe Amouyel,Zorayr Arzumanyan,Beverley Balkau,Lisa Bastarache,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Linda Broer,Amber A. Burt,Adam S. Butterworth,Mark J. Caulfield,Giancarlo Cesana,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Francis S. Collins,James P. Cook,Amanda J. Cox,David S. Crosslin,John Danesh,Paul I.W. de Bakker,Simon de Denus,Renée de Mutsert,George Dedoussis,Ellen W. Demerath,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Marcus Dörr,Fotios Drenos,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Myriam Fornage,Caroline S. Fox,Paul W. Franks,Nele Friedrich,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Giorgia Girotto,Mathias Gorski,Harald Grallert,Niels Grarup,Megan L. Grove,Stefan Gustafsson,Jeffrey Haessler,Torben Hansen,Andrew T. Hattersley,Caroline Hayward,Iris M. Heid,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Yi-Jen Hung,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Gail P. Jarvik,Yucheng Jia,Torben Jørgenson,Pekka Jousilahti,Johanne Marie Justesen,Bratati Kahali,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Peter Kovacs,Bernhard K. Krämer,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Wen-Jane Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Jian'an Luan,Leo-Pekka Lyytikäinen,Stuart MacGregor,Reedik Mägi,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas Masca,Mark I. McCarthy,Karina Meidtner,Evelin Mihailov,Leena Moilanen,Marie Moitry,Dennis O. Mook-Kanamori,Anna Morgan,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Narisu Narisu,Christopher P. Nelson,Matt J. Neville,Ioanna Ntalla,Jeffrey R. O'Connel,Katharine R. Owen,Oluf Pedersen,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Ailith Pirie,Ozren Polasek,Olli T. Raitakari,Asif Rasheed,Chelsea K. Raulerson,Rainer Rauramaa,Dermot F. Reilly,Alex P. Reiner,Paul M. Ridker,Manuel A. Rivas,Neil R. Robertson,Antonietta Robino,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Blair H. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Karin M. A. Swart,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Mina Torres,Emmanouil Tsafantakis,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Cornelia M. van Duijn,Mauno Vanhala,Rohit Varma,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,M. Carola Zillikens,Fernando Rivadeneira,Ingrid B. Borecki,John Andrew Pospisilik,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Karen L. Mohlke,Jerome I. Rotter,Zoltán Kutalik,Joel N. Hirschhorn,L. Adrienne Cupples,Ruth J. F. Loos,Kari E. North,Cecilia M. Lindgren +278 more
TL;DR: By examining variants often poorly tagged or entirely missed by genome-wide association studies, novel genes in fat distribution are implicate, stressing the importance of interrogating low-frequency and protein-coding variants.
Journal ArticleDOI
Regression-based sib pair linkage analysis for binary traits
TL;DR: These studies showed that the new HE method is well-behaved under the null hypothesis in large samples, is more powerful than both the original and the revisited HE methods, and is approximately equivalent in power to the liability-threshold VC model.