G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Posted ContentDOI
Proper conditional analysis in the presence of missing data identified novel independently associated low frequency variants in nicotine dependence genes
Bibo Jiang,Sai Chen,Yu Jiang,Mengzhen Liu,William G. Iacono,John K. Hewitt,John E. Hokanson,Kenneth Krauter,Markku Laakso,Kevin Li,Sharon M. Lutz,Matt McGue,Daniel McGuire,Anita Pandit,Gregory J.M. Zajac,Michael Boehnke,Gonçalo R. Abecasis,Scott I. Vrieze,Xiaowei Zhan,Dajiang J. Liu +19 more
TL;DR: A method to combine summary statistics across participating studies and consistently estimate joint effects, even when the contributed summary statistics contain large amount of missing values is developed, and a score statistic is proposed called PCBS (partial correlation based score statistic) for conditional analysis of single-variant and gene-level associations.
COL4A1 Is Associated With Arterial Stiffness By Genome Wide Association Scan. Tarasov et al. COL4A1 is Associated with PWV by GWAS
Kirill V. Tarasov,Serena Sanna,Angelo Scuteri,Marco Orrù,Afshin Parsa,Ping-I Lin,Andrea Maschio,Sandra Lai,Maria Grazia Piras,Marco Masala,Toshiko Tanaka,Antonio Cao,Ramaiah Nagaraja,Braxton D. Mitchell,Gonçalo R. Abecasis,Alan R. Shuldiner,Manuela Uda,Samer S. Najjar +17 more
Journal ArticleDOI
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
Tanika N. Kelly,Xiao Sun,Karen Y. He,Sarah A Gagliano Taliun,Jacklyn N. Hellwege,Marguerite R. Irvin,Xuenan Mi,Jennifer A. Brody,Nora Franceschini,Xiuqing Guo,Shih-Jen Hwang,Paul S. de Vries,Yan Gao,Arden Moscati,Girish N. Nadkarni,Lisa R. Yanek,Tali Elfassy,Jennifer A. Smith,Ren-Hua Chung,Amber L. Beitelshees,Amit Patki,Stella Aslibekyan,Brandon M. Blobner,Juan M. Peralta,Themistocles L. Assimes,Walter Palmas,Chunyu Liu,Adam P. Bress,Zhijie Huang,Lewis C. Becker,Chii-Min Hwa,Jeffrey R. O'Connell,Jenna C. Carlson,Helen R. Warren,Sayantan Das,Ayush Giri,Lisa W. Martin,W. Craig Johnson,Ervin R. Fox,Erwin P. Bottinger,Alexander C. Razavi,Dhananjay Vaidya,Lee-Ming Chuang,Yen Pei C. Chang,Take Naseri,Deepti Jain,Hyun Min Kang,Adriana M. Hung,Vinodh Srinivasasainagendra,Beverly M. Snively,Dongfeng Gu,May E. Montasser,Muagututi‘a Sefuiva Reupena,Benjamin D. Heavner,Jonathon LeFaive,James E. Hixson,Kenneth Rice,Fei Fei Wang,Jonas B. Nielsen,Jianfeng Huang,Alyna T. Khan,Wei Zhou,Jovia L. Nierenberg,Cathy C. Laurie,N. Armstrong,Mengyao Shi,Ya-Feng Pan,Adrienne M. Stilp,Leslie S. Emery,Quenna Wong,Nicola L. Hawley,Ryan L. Minster,Joanne E. Curran,Patricia B. Munroe,Daniel E. Weeks,Kari E. North,Russell P. Tracy,Eimear E. Kenny,Daichi Shimbo,Aravinda Chakravarti,Stephen S. Rich,Alexander P. Reiner,John Blangero,Susan Redline,Braxton D. Mitchell,Dabeeru C. Rao,Yii-Der Ida Chen,Sharon L.R. Kardia,Robert C. Kaplan,Rasika A. Mathias,Jiang He,Bruce M. Psaty,Myriam Fornage,Ruth J. F. Loos,Adolfo Correa,Eric Boerwinkle,Jerome I. Rotter,Charles Kooperberg,Todd L. Edwards,Gonçalo R. Abecasis,Xiaofeng Zhu,Daniel Levy,Donna K. Arnett,Alanna C. Morrison +103 more
TL;DR: One promising but unconfirmed rare variant for blood pressure is reported and the findings suggest promise of aggregate analyses to complement single variant analysis strategies and the need for larger, diverse samples, and family studies to enable robust rare variant identification.
Journal ArticleDOI
Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium.
Stephen Sanders,Benjamin M. Neale,Benjamin M. Neale,Hailiang Huang,Hailiang Huang,Donna M. Werling,Joon Yong An,Shan Dong,Gonçalo R. Abecasis,P. Alexander Arguello,John Blangero,Michael Boehnke,Mark J. Daly,Mark J. Daly,Kevin Eggan,Daniel H. Geschwind,David C. Glahn,David Goldstein,Raquel E. Gur,Robert E. Handsaker,Steven A. McCarroll,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Aarno Palotie,Carlos N. Pato,Chiara Sabatti,Matthew W. State,A. Jeremy Willsey,Steven E. Hyman,Anjené M. Addington,Thomas Lehner,Nelson B. Freimer +32 more
TL;DR: In the version of this article initially published, the consortium authorship and corresponding authors were not presented correctly and the errors have been corrected in the HTML and PDF versions of the article.
Posted ContentDOI
Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior
Dajiang J. Liu,David M. Brazel,Turcot,Xiaowei Zhan,Jian Gong,Daniel R. Barnes,Sarah Bertelsen,Yi Ling Chou,A. Mesut Erzurumluoglu,Jessica D. Faul,Jeff Haessler,Anke R. Hammerschlag,Chris Hsu,Manav Kapoor,Dongbing Lai,Nhung Le,Christiaan de Leeuw,Anu Loukola,Massimo Mangino,Carl A. Melbourne,Giorgio Pistis,Beenish Qaiser,Rebecca Rohde,Yaming Shao,Heather M. Stringham,Leah Wetherill,Wei Zhao,Arpana Agrawal,Laura J. Bierut,Chu Chen,Charles B. Eaton,Alison Goate,Christopher A. Haiman,Andrew C. Heath,William G. Iacono,Nicholas G. Martin,Tinca J. C. Polderman,Alex P. Reiner,John P. Rice,David Schlessinger,H. Steven Scholte,Jennifer A. Smith,Jean-Claude Tardif,Hilary A. Tindle,Andries R. van der Leij,Michael Boehnke,Jenny Chang-Claude,Francesco Cucca,Sean P. David,Tatiana Foroud,Sharon L.R. Kardia,Charles Kooperberg,Markku Laakso,Guillaume Lettre,Pamela A. F. Madden,Matt McGue,Kari E. North,Danielle Posthuma,Tim D. Spector,Daniel O. Stram,David R. Weir,Jaakko Kaprio,Gonçalo R. Abecasis,Scott I. Vrieze +63 more
TL;DR: The findings indicate that rare coding variants contribute to phenotypic variation, but that much larger samples and/or denser genotyping of rare variants will be required to successfully identify associations with these phenotypes, whether individual variants or gene‐ based associations.