G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Age-Related Macular Degeneration: Genetics and Biology Coming Together
Lars G. Fritsche,Robert N. Fariss,Dwight Stambolian,Gonçalo R. Abecasis,Christine A. Curcio,Anand Swaroop +5 more
TL;DR: A critical review of the ongoing genetic studies and of common and rare risk variants at a total of 20 susceptibility loci, which together explain 40-60% of the disease heritability but provide limited power for diagnostic testing of disease risk.
Journal ArticleDOI
Common variants at ten loci modulate the QT interval duration in the QTSCD Study
Arne Pfeufer,Serena Sanna,Dan E. Arking,Martina Müller,Vesela Gateva,Christian Fuchsberger,Georg B. Ehret,Marco Orr,Cristian Pattaro,Anna Köttgen,Siegfried Perz,Gianluca Usala,Maja Barbalić,Man Li,Benno Pütz,Angelo Scuteri,Ronald J. Prineas,Moritz F. Sinner,Christian Gieger,Samer S. Najjar,W. H. Linda Kao,Thomas W. Mühleisen,Mariano Dei,Christine Happle,Stefan Möhlenkamp,Laura Crisponi,Raimund Erbel,K. H. Jöckel,Silvia Naitza,Gerhard Steinbeck,Fabio Marroni,Andrew A. Hicks,Edward G. Lakatta,Bertram Müller-Myhsok,Peter P. Pramstaller,H.-Erich Wichmann,David Schlessinger,Eric Boerwinkle,Thomas Meitinger,Manuela Uda,Josef Coresh,Stefan Kääb,Gonçalo R. Abecasis,Aravinda Chakravarti +43 more
TL;DR: In this article, the authors analyzed genome-wide data from five population-based cohorts (ARIC, KORA, SardiNIA, GenNOVA and HNR) with a total of 15,842 individuals of European ancestry, to confirm the NOS1AP association and identify nine additional loci at P < 5 x 10(-8).
Journal ArticleDOI
FTO genotype is associated with phenotypic variability of body mass index
Jian Yang,Jian Yang,Ruth J. F. Loos,Ruth J. F. Loos,Joseph E. Powell,Joseph E. Powell,Sarah E. Medland,Elizabeth K. Speliotes,Daniel I. Chasman,Lynda M. Rose,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Reedik Mägi,Reedik Mägi,Lindsay L. Waite,Albert V. Smith,Laura M. Yerges-Armstrong,Keri L. Monda,David Hadley,Anubha Mahajan,Guo Li,Karen Kapur,Karen Kapur,Veronique Vitart,Jennifer E. Huffman,Sophie R. Wang,Sophie R. Wang,Cameron D. Palmer,Cameron D. Palmer,Tõnu Esko,Krista Fischer,Jing Hua Zhao,Ayse Demirkan,Aaron Isaacs,Mary F. Feitosa,Jian'an Luan,Nancy L. Heard-Costa,Charles S. White,Anne U. Jackson,Michael Preuss,Andreas Ziegler,Joel Eriksson,Zoltán Kutalik,Francesca Frau,Ilja M. Nolte,Jana V. van Vliet-Ostaptchouk,Jouke-Jan Hottenga,Kevin B. Jacobs,Niek Verweij,Anuj Goel,Carolina Medina-Gomez,Karol Estrada,Jennifer L. Bragg-Gresham,Serena Sanna,Carlo Sidore,Carlo Sidore,Jonathan Tyrer,Alexander Teumer,Inga Prokopenko,Massimo Mangino,Cecilia M. Lindgren,Themistocles L. Assimes,Alan R. Shuldiner,Alan R. Shuldiner,Jennie Hui,John Beilby,Wendy L. McArdle,Per Hall,Talin Haritunians,Lina Zgaga,Lina Zgaga,Ivana Kolcic,Ozren Polasek,Tatijana Zemunik,Ben A. Oostra,M. Juhani Junttila,Henrik Grönberg,Stefan Schreiber,Annette Peters,Andrew A. Hicks,Jonathan Stephens,Jonathan Stephens,Nicola S. Foad,Nicola S. Foad,Jaana Laitinen,Anneli Pouta,Anneli Pouta,Marika Kaakinen,Gonneke Willemsen,Jacqueline M. Vink,Sarah H Wild,Gerjan Navis,Folkert W. Asselbergs,Georg Homuth,Ulrich John,Carlos Iribarren,Tamara B. Harris,Lenore J. Launer,Vilmundur Gudnason,Jeffrey R. O'Connell,Eric Boerwinkle,Gemma Cadby,Lyle J. Palmer,Alan James,Arthur W. Musk,Erik Ingelsson,Bruce M. Psaty,Bruce M. Psaty,Jacques S. Beckmann,Gerard Waeber,Peter Vollenweider,Caroline Hayward,Alan F. Wright,Igor Rudan,Igor Rudan,Leif Groop,Andres Metspalu,Kay-Tee Khaw,Cornelia M. van Duijn,Ingrid B. Borecki,Michael A. Province,Nicholas J. Wareham,Jean-Claude Tardif,Heikki V. Huikuri,L. Adrienne Cupples,Larry D. Atwood,Caroline S. Fox,Michael Boehnke,Francis S. Collins,Karen L. Mohlke,Jeanette Erdmann,Heribert Schunkert,Christian Hengstenberg,Klaus Stark,Mattias Lorentzon,Claes Ohlsson,Daniele Cusi,Jan A. Staessen,Jan A. Staessen,Melanie M. van der Klauw,Peter P. Pramstaller,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Jennifer Jolley,Jennifer Jolley,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Eco J. C. de Geus,Dorret I. Boomsma,Brenda W. J. H. Penninx,James F. Wilson,Harry Campbell,Stephen J. Chanock,Pim van der Harst,Anders Hamsten,Hugh Watkins,Albert Hofman,Jacqueline C. M. Witteman,M. Carola Zillikens,André G. Uitterlinden,Fernando Rivadeneira,Lambertus A. Kiemeney,Sita H. Vermeulen,Gonçalo R. Abecasis,David Schlessinger,Sabine Schipf,Michael Stumvoll,Anke Tönjes,Tim D. Spector,Kari E. North,Guillaume Lettre,Mark I. McCarthy,Sonja I. Berndt,Andrew C. Heath,Pamela A. F. Madden,Dale R. Nyholt,Grant W. Montgomery,Nicholas G. Martin,Barbara McKnight,David P. Strachan,William G. Hill,Harold Snieder,Paul M. Ridker,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Timothy M. Frayling,Joel N. Hirschhorn,Joel N. Hirschhorn,Michael E. Goddard,Michael E. Goddard,Peter M. Visscher,Peter M. Visscher +198 more
TL;DR: The authors performed a meta-analysis of genome-wide association studies of phenotypic variation using ∼170,000 samples on height and body mass index (BMI) in human populations.
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan,Daniel Taliun,Matthias Thurner,Neil R. Robertson,Jason M. Torres,N. William Rayner,Anthony Payne,Valgerdur Steinthorsdottir,Robert A. Scott,Niels Grarup,James P. Cook,Ellen M. Schmidt,Matthias Wuttke,Chloé Sarnowski,Reedik Magill,Jana Nano,Christian Gieger,Stella Trompet,Cécile Lecoeur,Michael Preuss,Bram P. Prins,Xiuqing Guo,Lawrence F. Bielak,Jennifer E. Below,Donald W. Bowden,John C. Chambers,Young-Jin Kim,Maggie C.Y. Ng,Lauren E. Petty,Xueling Sim,Weihua Zhang,Amanda J. Bennett,Jette Bork-Jensen,Chad M. Brummett,Mickaël Canouil,Kai-Uwe Ec Kardt,Krista Fischer,Sharon L.R. Kardia,Florian Kronenberg,Kristi Läll,Ching-Ti Liu,Adam E. Locke,Jian'an Luan,Loanna Ntalla,Vibe Nylander,Sebastian Schoenherr,Claudia Schurmann,Loic Yengo,Erwin P. Bottinger,Ivan Brandslund,Cramer Christensen,George Dedoussis,Jose C. Florez,Ian Ford,Timothy M. Frayling,Vilmantas Giedraitis,Sophie Hackinger,Andrew T. Hattersley,Christian Herder,M. Arfan Ikram,Martin Ingelsson,Marit E. Jørgensen,Torben Jørgensen,Jennifer Kriebel,Johanna Kuusisto,Symen Ligthart,Cecilia M. Lindgren,Allan Linneberg,Valeriya Lyssenko,Vasiliki Mamakou,Thomas Meitinger,Karen L. Mohlke,Andrew D. Morris,Girish N. Nadkarni,James S. Pankow,Annette Peters,Naveed Sattar,Alena Stančáková,Konstantin Strauch,Kent D. Taylor,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Jaakko Tuomilehto,Daniel R. Witte,Josée Dupuis,Patricia A. Peyser,Eleftheria Zeggini,Ruth J. F. Loos,Philippe Froguel,Erik Ingelsson,Lars Lind,Leif Groop,Markku Laakso,Francis S. Collins,J. Wouter Jukema,Colin N. A. Palmer,Harald Grallert,Andres Metspalu,Abbas Dehghan,Anna Koettgen,Gonçalo R. Abecasis,James B. Meigs,Rotter, Jerome, I,Jonathan Marchini,Oluf Pedersen,Torben Hansen,Claudia Langenberg,Nicholas J. Wareham,Kari Stefansson,Anna L. Gloyn,Andrew P. Morris,Michael Boehnke,McCarthy, Mark, I +113 more
Abstract: We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight.
Journal ArticleDOI
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Manuel A. R. Ferreira,Judith M. Vonk,Hansjörg Baurecht,Ingo Marenholz,Ingo Marenholz,Chao Tian,Joshua D. Hoffman,Quinta Helmer,Annika Tillander,Vilhelmina Ullemar,Jenny van Dongen,Yi Lu,Franz Rüschendorf,Jorge Esparza-Gordillo,Jorge Esparza-Gordillo,Jorge Esparza-Gordillo,Chris W. Medway,Edward Mountjoy,Kimberley Burrows,Oliver Hummel,Sarah Grosche,Sarah Grosche,Ben Michael Brumpton,Ben Michael Brumpton,John S. Witte,Jouke-Jan Hottenga,Gonneke Willemsen,Jie Zheng,Elke Rodriguez,Melanie Hotze,Andre Franke,Joana A. Revez,Jonathan Beesley,Melanie C. Matheson,Shyamali C. Dharmage,L. Bain,Lars G. Fritsche,Maiken Elvestad Gabrielsen,Brunilda Balliu,Jonas B. Nielsen,Wei Zhou,Kristian Hveem,Arnulf Langhammer,Oddgeir L. Holmen,Mari Løset,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Cristen J. Willer,Andreas Arnold,Georg Homuth,Carsten Oliver Schmidt,Philip J. Thompson,Nicholas G. Martin,David L. Duffy,Natalija Novak,Holger Schulz,Stefan Karrasch,Christian Gieger,Konstantin Strauch,Ronald B. Melles,David A. Hinds,Norbert Hubner,Stephan Weidinger,Patrik K. E. Magnusson,Rick Jansen,Eric Jorgenson,Young-Ae Lee,Young-Ae Lee,Dorret I. Boomsma,Catarina Almqvist,Catarina Almqvist,Robert Karlsson,Gerard H. Koppelman,Lavinia Paternoster +73 more
TL;DR: A genome-wide association study of a broad allergic disease phenotype that considers the presence of any one of these three diseases identified 136 independent risk variants, including 73 not previously reported, which implicate 132 nearby genes in allergic disease pathophysiology.