G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Exploring and visualizing large-scale genetic associations by using PheWeb
Sarah A Gagliano Taliun,Peter VandeHaar,Andrew P. Boughton,Ryan P. Welch,Daniel Taliun,Ellen M. Schmidt,Wei Zhou,Jonas B. Nielsen,Cristen J. Willer,Seunggeun Lee,Lars G. Fritsche,Michael Boehnke,Gonçalo R. Abecasis,Gonçalo R. Abecasis +13 more
TL;DR: PheWeb is an easy-to-use open-source web-based tool for visualizing, navigating and sharing GWAS and PheWAS results, used to explore association results for large datasets such as the UK Biobank5 and the Michigan Genomics Initiative, and organizes relationships between traits on the basis of pairwise genetic correlations.
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Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking
Antonio Terracciano,Tõnu Esko,Tõnu Esko,Angelina R. Sutin,M.H.M. de Moor,Osorio Meirelles,Gu Zhu,Toshiko Tanaka,Ina Giegling,Teresa Nutile,Anu Realo,Jüri Allik,Narelle K. Hansell,Margie Wright,Grant W. Montgomery,Gonneke Willemsen,J-J Hottenga,Marion Friedl,Daniela Ruggiero,Rossella Sorice,Serena Sanna,Alessandra Cannas,Katri Räikkönen,Elisabeth Widen,Aarno Palotie,Aarno Palotie,Johan G. Eriksson,Francesco Cucca,Robert F. Krueger,Jari Lahti,Michelle Luciano,Jordan W. Smoller,C M van Duijn,Gonçalo R. Abecasis,Dorret I. Boomsma,Marina Ciullo,Paul T. Costa,Luigi Ferrucci,Nicholas G. Martin,Andres Metspalu,Andres Metspalu,Dan Rujescu,David Schlessinger,Manuela Uda +43 more
TL;DR: In this paper, the authors identified a genome-wide significant association between the Revised NEO Personality Inventory and rs7600563 (P=2 × 10−8), a single-nucleotide polymorphism mapped within the catenin cadherin-associated protein, alpha 2 (CTNNA2), which encodes for a brain-expressed α-catenin critical for synaptic contact.
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Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes
Kyle J. Gaulton,Cristen J. Willer,Yun Li,Laura J. Scott,Karen N. Conneely,Anne U. Jackson,William L. Duren,Peter S. Chines,Narisu Narisu,Lori L. Bonnycastle,Jingchun Luo,Maurine Tong,Andrew G. Sprau,Elizabeth W. Pugh,Kimberly F. Doheny,Timo T. Valle,Gonçalo R. Abecasis,Jaakko Tuomilehto,Jaakko Tuomilehto,Richard N. Bergman,Francis S. Collins,Michael Boehnke,Karen L. Mohlke +22 more
TL;DR: This study provides an effective gene-based approach to association study design and analysis and implicated novel genes, including RAPGEF1 and TP53, in type 2 diabetes susceptibility.
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Efficient Study Designs for Test of Genetic Association Using Sibship Data and Unrelated Cases and Controls
TL;DR: The likelihood-based method of Li et al., which assesses whether there is linkage disequilibrium between a disease locus and a SNP is extended to accommodate sibships of arbitrary size and disease-phenotype configuration, suggests that when the disease is influenced by a single gene, the one sibling per ASP-control design is the most efficient.
Journal ArticleDOI
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.
Satria Sajuthi,Peter Deford,Yingchun Li,Nathan D. Jackson,M.T. Montgomery,Jamie L. Everman,Cydney Rios,Elmar Pruesse,James D. Nolin,Elizabeth G. Plender,Michael E. Wechsler,Angel C.Y. Mak,Celeste Eng,Sandra Salazar,Vivian Medina,Eric M. Wohlford,Scott Huntsman,Deborah A. Nickerson,Soren Germer,Michael C. Zody,Gonçalo R. Abecasis,Hyun Min Kang,Kenneth Rice,Rajesh Kumar,Sam S. Oh,Jose R. Rodriguez-Santana,Esteban G. Burchard,Max A. Seibold +27 more
TL;DR: Airway responses to common coronavirus infections in children are defined, finding that these infections generate host responses similar to other viral species, including upregulation of IL6 and ACE2.