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Gonçalo R. Abecasis

Researcher at University of Michigan

Publications -  629
Citations -  271012

Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.

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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Jason Flannick, +163 more
TL;DR: The authors used exome-sequencing analyses of a large cohort of patients with Type 2 diabetes and control individuals without diabetes from five ancestries to identify gene-level associations of rare variants that are associated with type 2 diabetes.
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Sequence features in regions of weak and strong linkage disequilibrium

Albert V. Smith, +3 more
- 01 Nov 2005 - 
TL;DR: Genotype data generated by the International HapMap Project is used to dissect the relationship between sequence features and the degree of linkage disequilibrium in the genome and suggest an evolutionary justification for the heterogeneity in linkage disequ equilibrium.
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Height-reducing variants and selection for short stature in Sardinia.

Magdalena Zoledziewska, +32 more
- 01 Nov 2015 - 
TL;DR: Se sequencing-based whole-genome association analyses to evaluate the impact of rare and founder variants on stature in 6,307 individuals on the island of Sardinia show consistent with selection for shorter stature in Sardinia and a suggestive human example of the proposed 'island effect' reducing the size of large mammals.

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Anne E. Justice, +316 more
TL;DR: In this paper, the authors used GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI.
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The Power to Detect Linkage Disequilibrium with Quantitative Traits in Selected Samples

Gonçalo R. Abecasis, +2 more
- 01 Jun 2001 - 
TL;DR: Analysis of the role of allele frequencies within each selection design indicates that common trait alleles generally offer the most power, but similarities between the marker- and trait-allele frequencies are much more important than the trait-locus frequency alone.