G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Linkage disequilibrium: ancient history drives the new genetics.
TL;DR: The importance of using appropriate statistical procedures, such as the false discovery rate, to maximize the chances of success in large scale association studies is highlighted.
Journal ArticleDOI
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Alisa K. Manning,Alisa K. Manning,Heather M. Highland,Heather M. Highland,Jessica A. Gasser,Xueling Sim,Taru Tukiainen,Taru Tukiainen,Pierre Fontanillas,Niels Grarup,Manuel A. Rivas,Anubha Mahajan,Adam E. Locke,Pablo Cingolani,Tune H. Pers,Ana Viñuela,Ana Viñuela,Andrew A. Brown,Andrew A. Brown,Ying Wu,Jason Flannick,Jason Flannick,Christian Fuchsberger,Eric R. Gamazon,Kyle J. Gaulton,Kyle J. Gaulton,Hae Kyung Im,Tanya M. Teslovich,Thomas W. Blackwell,Jette Bork-Jensen,Noël P. Burtt,Yuhui Chen,Todd Green,Christopher Hartl,Hyun Min Kang,Ashok Kumar,Ashok Kumar,Claes Ladenvall,Clement Ma,Loukas Moutsianas,Richard D. Pearson,John R. B. Perry,John R. B. Perry,John R. B. Perry,N. William Rayner,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Laura J. Scott,Martijn van de Bunt,Martijn van de Bunt,Johan G. Eriksson,Antti Jula,Seppo Koskinen,Terho Lehtimäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Suzanne B.R. Jacobs,Jennifer Wessel,Audrey Y. Chu,Robert A. Scott,Mark O. Goodarzi,Christine Blancher,Gemma Buck,David Buck,Peter S. Chines,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Joseph Trakalo,Eric Banks,Jason Carey,Mauricio O. Carneiro,Mark A. DePristo,Yossi Farjoun,Timothy Fennell,Jacqueline I. Goldstein,Jacqueline I. Goldstein,George B. Grant,Martin Hrabé de Angelis,Jared Maguire,Benjamin M. Neale,Benjamin M. Neale,Ryan Poplin,Shaun Purcell,Shaun Purcell,Shaun Purcell,Thomas Schwarzmayr,Khalid Shakir,Joshua D. Smith,Tim M. Strom,Thomas Wieland,Jaana Lindström,Ivan Brandslund,Cramer Christensen,Gabriela L. Surdulescu,Timo A. Lakka,Alex S. F. Doney,Peter M. Nilsson,Nicholas J. Wareham,Claudia Langenberg,Tibor V. Varga,Paul W. Franks,Paul W. Franks,Paul W. Franks,Olov Rolandsson,Anders Rosengren,Vidya S. Farook,Farook Thameem,Sobha Puppala,Satish Kumar,Donna M. Lehman,Christopher P. Jenkinson,Joanne E. Curran,Daniel E. Hale,Sharon P. Fowler,Rector Arya,Ralph A. DeFronzo,Hanna E. Abboud,Ann-Christine Syvänen,Pamela J. Hicks,Nicholette D. Palmer,Maggie C.Y. Ng,Donald W. Bowden,Barry I. Freedman,Tõnu Esko,Reedik Mägi,Lili Milani,Evelin Mihailov,Andres Metspalu,Narisu Narisu,Leena Kinnunen,Lori L. Bonnycastle,Amy J. Swift,Dorota Pasko,Andrew R. Wood,João Fadista,Toni I. Pollin,Nir Barzilai,Gil Atzmon,Benjamin Glaser,Barbara Thorand,Konstantin Strauch,Annette Peters,Michael Roden,Martina Müller-Nurasyid,Liming Liang,Jennifer Kriebel,Thomas Illig,Harald Grallert,Christian Gieger,Christa Meisinger,Lars Lannfelt,Solomon K. Musani,Michael Griswold,Herman A. Taylor,Gregory A Wilson,Adolfo Correa,Heikki Oksa,William R. Scott,Uzma Afzal,Sian-Tsung Tan,Marie Loh,Marie Loh,Marie Loh,John C. Chambers,John C. Chambers,John C. Chambers,Jobanpreet Sehmi,Jaspal S. Kooner,Benjamin Lehne,Yoon Shin Cho,Jong-Young Lee,Bok-Ghee Han,Annemari Käräjämäki,Qibin Qi,Qibin Qi,Lu Qi,Lu Qi,Jinyan Huang,Frank B. Hu,Olle Melander,Marju Orho-Melander,Jennifer E. Below,David Aguilar,Tien Yin Wong,Jianjun Liu,Jianjun Liu,Chiea Chuen Khor,Kee Seng Chia,Wei-Yen Lim,Ching-Yu Cheng,Edmund Chan,E. Shyong Tai,Tin Aung,Allan Linneberg,Allan Linneberg,Bo Isomaa,Thomas Meitinger,Tiinamaija Tuomi,Liisa Hakaste,Jasmina Kravic,Marit E. Jørgensen,Torsten Lauritzen,Panos Deloukas,Kathleen Stirrups,Kathleen Stirrups,Katharine R. Owen,Andrew Farmer,Timothy M. Frayling,Stephen O'Rahilly,Mark Walker,Jonathan C. Levy,Dylan Hodgkiss,Andrew T. Hattersley,Teemu Kuulasmaa,Alena Stančáková,Inês Barroso,Inês Barroso,Dwaipayan Bharadwaj,Juliana C.N. Chan,Giriraj R. Chandak,Mark J. Daly,Peter Donnelly,Peter Donnelly,Shah Ebrahim,Paul Elliott,Tasha E. Fingerlin,Philippe Froguel,Cheng Hu,Weiping Jia,Ronald C.W. Ma,Gilean McVean,Taesung Park,Dorairaj Prabhakaran,Manjinder S. Sandhu,Manjinder S. Sandhu,James Scott,Robert Sladek,Nikhil Tandon,Yik Ying Teo,Eleftheria Zeggini,Richard M. Watanabe,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Y. Antero Kesäniemi,Matti Uusitupa,Tim D. Spector,Veikko Salomaa,Rainer Rauramaa,Colin N. A. Palmer,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Andrew D. Morris,Richard N. Bergman,Francis S. Collins,Lars Lind,Erik Ingelsson,Jaakko Tuomilehto,Fredrik Karpe,Leif Groop,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Oluf Pedersen,Johanna Kuusisto,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Mark Seielstad,Mark Seielstad,James G. Wilson,Josée Dupuis,Samuli Ripatti,Samuli Ripatti,Craig L. Hanis,Jose C. Florez,Karen L. Mohlke,James B. Meigs,James B. Meigs,Markku Laakso,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,David Altshuler,Mark I. McCarthy,Mark I. McCarthy,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren +312 more
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.
Journal ArticleDOI
Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19
John Blangero,Tanya M. Teslovich,Xueling Sim,Marcio Almeida,Goo Jun,Goo Jun,Thomas D. Dyer,Matthew P. Johnson,Juan M. Peralta,Alisa K. Manning,Andrew R. Wood,Christian Fuchsberger,Jack W. Kent,David A. Aguilar,Jennifer E. Below,Vidya S. Farook,Rector Arya,Sharon P. Fowler,Thomas W. Blackwell,Sobha Puppala,Satish Kumar,David C. Glahn,Eric K. Moses,Joanne E. Curran,Farook Thameem,Christopher P. Jenkinson,Ralph A. DeFronzo,Donna M. Lehman,Craig L. Hanis,Gonçalo R. Abecasis,Michael Boehnke,Harald H H Göring,Ravindranath Duggirala,Laura Almasy,Laura Almasy +34 more
TL;DR: The GAW19 data are an expansion of the data used at GAW18, which included the family-based whole genome sequence, blood pressure, and simulated phenotypes, but not the gene expression data or the set of 1943 unrelated individuals with exome sequence.
Journal ArticleDOI
Inflammation in the pathogenesis of age-related macular degeneration.
TL;DR: Age-related macular degeneration primarily affects the macular region of the retina; early signs of the disease include the appearance of soft drusen and regions of altered pigmentation in the retina, whereas advanced stages exhibit choroidal neovascularisation or atrophy of photoreceptors and the retinal pigment epithelium.
Posted ContentDOI
GAS Power Calculator: web-based power calculator for genetic association studies
TL;DR: The Genetic Association Study (GAS) Power Calculator is developed to provide users with a simple interface that can be compute the power of genetic association studies in a convenient browser based interface.