G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Mathias Gorski,Mathias Gorski,Bettina Jung,Yong Li,Pamela R. Matias-Garcia,Matthias Wuttke,Stefan Coassin,Chris H. L. Thio,Marcus E. Kleber,Thomas W. Winkler,Veronika Wanner,Jin-Fang Chai,Audrey Y. Chu,Massimiliano Cocca,Mary F. Feitosa,Sahar Ghasemi,Anselm Hoppmann,Katrin Horn,Man Li,Teresa Nutile,Markus Scholz,Karsten B. Sieber,Alexander Teumer,Adrienne Tin,Judy Wang,Bamidele O. Tayo,Tarunveer S. Ahluwalia,Peter Almgren,Stephan J. L. Bakker,Bernhard Banas,Nisha Bansal,Mary L. Biggs,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Hermann Brenner,Hermann Brenner,Robert J. Carroll,John Chalmers,John Chalmers,Miao-Li Chee,Miao-Ling Chee,Ching-Yu Cheng,Ching-Yu Cheng,Josef Coresh,Martin H. de Borst,Frauke Degenhardt,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Karlhans Endlich,Andre Franke,Sandra Freitag-Wolf,Piyush Gampawar,Ron T. Gansevoort,Mohsen Ghanbari,Mohsen Ghanbari,Christian Gieger,Pavel Hamet,Kevin Ho,Edith Hofer,Bernd Holleczek,Valencia Hui Xian Foo,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Navya Shilpa Josyula,Mika Kähönen,Chiea Chuen Khor,Chiea Chuen Khor,Wolfgang Koenig,Wolfgang Koenig,Holly Kramer,Bernhard K. Krämer,Brigitte Kühnel,Leslie A. Lange,Terho Lehtimäki,Wolfgang Lieb,Behrooz Z. Alizadeh,H. Marike Boezen,Lude Franke,Pim van der Harst,Gerjan Navis,Marianne Rots,Harold Snieder,Morris Swertz,Bruce H.R. Wolffenbuttel,Cisca Wijmenga,Gonçalo R. Abecasis,A. Baras,Michael Cantor,Giovanni Coppola,Aris Economides,Luca A. Lotta,John D. Overton,Jeffrey G. Reid,A. R. Shuldiner,Christina Beechert,Caitlin Forsythe,Erin D. Fuller,Zhenhua Gu,Michael Lattari,Alexander Lopez,Thomas D. Schleicher,Maria Sotiropoulos Padilla,Karina Toledo,Louis Widom,Sarah E. Wolf,Manasi Pradhan,Kia Manoochehri,Ricardo H. Ulloa,Xiaodong Bai,Suganthi Balasubramanian,Leland Barnard,Andrew Blumenfeld,Gisu Eom,Lukas Habegger,Alicia Hawes,Shareef Khalid,Evan Maxwell,William Salerno,Jeffrey C. Staples,Marcus B. Jones,Lyndon J. Mitnaul,Ruth J. F. Loos,Mary Ann Lukas,Leo-Pekka Lyytikäinen,Christa Meisinger,Thomas Meitinger,Olle Melander,Yuri Milaneschi,Pashupati P. Mishra,Nina Mononen,Josyf C. Mychaleckyj,Girish N. Nadkarni,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Michelle L. O'Donoghue,Marju Orho-Melander,Sarah A. Pendergrass,Brenda W.J.H. Penninx,Michael Preuss,Bruce M. Psaty,Bruce M. Psaty,Laura M. Raffield,Olli T. Raitakari,Olli T. Raitakari,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Alexander R. Rosenkranz,Peter Rossing,Jerome I. Rotter,Charumathi Sabanayagam,Charumathi Sabanayagam,Helena Schmidt,Reinhold Schmidt,Ben Schöttker,Ben Schöttker,Christina-Alexandra Schulz,Sanaz Sedaghat,Sanaz Sedaghat,Christian M. Shaffer,Konstantin Strauch,Silke Szymczak,Kent D. Taylor,Johanne Tremblay,Layal Chaker,Peter J. van der Most,Niek Verweij,Uwe Völker,Melanie Waldenberger,Lars Wallentin,Dawn M. Waterworth,Harvey D. White,James G. Wilson,Tien Yin Wong,Tien Yin Wong,Mark Woodward,Mark Woodward,Qiong Yang,Masayuki Yasuda,Masayuki Yasuda,Laura M. Yerges-Armstrong,Yan Zhang,Christoph Wanner,Carsten A. Böger,Anna Köttgen,Anna Köttgen,Florian Kronenberg,Cristian Pattaro,Iris M. Heid +192 more
TL;DR: The identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Journal ArticleDOI
Characterization of ADME gene variation in 21 populations by exome sequencing.
Daniel H. Hovelson,Zhengyu Xue,Zhengyu Xue,Matthew Zawistowski,Margaret G. Ehm,Elizabeth C. Harris,Elizabeth C. Harris,Sophie L. Stocker,Annette S. Gross,In Jin Jang,Ichiro Ieiri,Ichiro Ieiri,Jong Eun Lee,Lon R. Cardon,Stephanie L. Chissoe,Gonçalo R. Abecasis,Matthew R. Nelson +16 more
TL;DR: Exome sequencing was effective in accurately genotyping most ADME variants important for pharmacogenetic research, in addition to identifying rare or potentially de novo coding variants that may be clinically meaningful.
Journal ArticleDOI
Psoriasis Bench to Bedside – Genetics Meets Immunology
Rajan P. Nair,Jun Ding,Kristina Callis Duffin,Cynthia Helms,John J. Voorhees,Gerald G. Krueger,Anne M. Bowcock,Gonçalo R. Abecasis,James T. Elder +8 more
TL;DR: The Collaborative Association Study of Psoriasis was initiated, whose objective was to carry out a genome-wide association scan and found significant associations at 3 genetic regions that had previously been …
Journal ArticleDOI
Ancestry-agnostic estimation of DNA sample contamination from sequence reads.
Fan Zhang,Matthew Flickinger,Sarah A Gagliano Taliun,Gonçalo R. Abecasis,Laura J. Scott,Steven A McCaroll,Steven A McCaroll,Carlos N. Pato,Michael Boehnke,Hyun Min Kang +9 more
TL;DR: A robust statistical method that accurately estimates DNA contamination and is agnostic to genetic ancestry of the intended or contaminating sample and integrates the estimation of genetic ancestry and DNA contamination in a unified likelihood framework by leveraging individual-specific allele frequencies projected from reference genotypes onto principal component coordinates.
Journal ArticleDOI
Fine mapping of eight psoriasis susceptibility loci
Sayantan Das,Philip E. Stuart,Jun Ding,Jun Ding,Trilokraj Tejasvi,Yanming Li,Lam C. Tsoi,Vinod Chandran,Judith Fischer,Cynthia Helms,Kristina Callis Duffin,John J. Voorhees,Anne M. Bowcock,Gerald G. Krueger,G. Mark Lathrop,Rajan P. Nair,Proton Rahman,Gonçalo R. Abecasis,Dafna D. Gladman,James T. Elder,James T. Elder +20 more
TL;DR: The results demonstrate allelic heterogeneity at IL12B and identify a high-risk MHC class I haplotype, consistent with the existence of multiple psoriasis effectors in the MHC, and find that SNP rs114255771 yielded a more significant association than any HLA allele or amino-acid residue.