G
Gonçalo R. Abecasis
Researcher at University of Michigan
Publications - 629
Citations - 271012
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 179, co-authored 595 publications receiving 230323 citations. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Journal ArticleDOI
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Jonas B. Nielsen,Jonas B. Nielsen,Oren Rom,Ida Surakka,Sarah E. Graham,Wei Zhou,Tanmoy Roychowdhury,Lars G. Fritsche,Lars G. Fritsche,Sarah A Gagliano Taliun,Carlo Sidore,Yuhao Liu,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Brooke N. Wolford,William Overton,Ying Zhao,Jin Chen,He Zhang,Whitney E. Hornsby,Akua Acheampong,Austen Grooms,Amanda Schaefer,Gregory J.M. Zajac,Luis Villacorta,Jifeng Zhang,Ben Michael Brumpton,Mari Løset,Vivek Rai,Pia R. Lundegaard,Pia R. Lundegaard,Morten S. Olesen,Morten S. Olesen,Kent D. Taylor,Nicholette D. Palmer,Yii Der Chen,Seung Hoan Choi,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor,Kathleen C. Barnes,Michelle Daya,Nicholas Rafaels,Scott T. Weiss,Scott T. Weiss,Jessica Lasky-Su,Jessica Lasky-Su,Russell P. Tracy,Ramachandran S. Vasan,L. Adrienne Cupples,Rasika A. Mathias,Lisa R. Yanek,Lewis C. Becker,Patricia A. Peyser,Lawrence F. Bielak,Jennifer A. Smith,Stella Aslibekyan,Bertha Hidalgo,Donna K. Arnett,Marguerite R. Irvin,James G. Wilson,Solomon K. Musani,Adolfo Correa,Stephen S. Rich,Xiuqing Guo,Jerome I. Rotter,Barbara A. Konkle,Jill M. Johnsen,Allison E. Ashley-Koch,Marilyn J. Telen,Vivien A. Sheehan,John Blangero,Joanne E. Curran,Juan M. Peralta,Courtney G. Montgomery,Wayne Huey-Herng Sheu,Ren-Hua Chung,Karen Schwander,Seyed Mehdi Nouraie,Victor R. Gordeuk,Yingze Zhang,Charles Kooperberg,Alexander P. Reiner,Alexander P. Reiner,Rebecca D. Jackson,Eugene R. Bleecker,Deborah A. Meyers,Xingnan Li,Sayantan Das,Ketian Yu,Jonathon LeFaive,Albert V. Smith,Thomas W. Blackwell,Daniel Taliun,Sebastian Zöllner,Lukas Forer,Sebastian Schoenherr,Christian Fuchsberger,Anita Pandit,Matthew Zawistowski,Sachin Kheterpal,Chad M. Brummett,Pradeep Natarajan,Pradeep Natarajan,David Schlessinger,Seunggeun Lee,Hyun Min Kang,Francesco Cucca,Oddgeir L. Holmen,Bjørn Olav Åsvold,Michael Boehnke,Sekar Kathiresan,Sekar Kathiresan,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Y. Eugene Chen,Cristen J. Willer,Kristian Hveem,Kristian Hveem +119 more
TL;DR: In this article, the authors performed genome-wide analyses of participants in the HUNT Study in Norway to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function.
Journal ArticleDOI
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Jason Flannick,Jason Flannick,Christian Fuchsberger,Anubha Mahajan,Tanya M. Teslovich,Vineeta Agarwala,Vineeta Agarwala,Kyle J. Gaulton,Lizz Caulkins,Ryan Koesterer,Clement Ma,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Ashok Kumar,Martina Müller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yuhui Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Bong Jo Kim,Yongkang Kim,Young Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok Ghee Han,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,B. Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Shaun Purcell,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,D Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Jianjun Liu,Marie Loh,Marie Loh,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian Tsung Tan,Sian Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Tien Yin Wong,Pål R. Njølstad,J C Levy,Massimo Mangino,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy R. Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Panos Deloukas,Panos Deloukas,Anette P. Gjesing,Goo Jun,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,B Thorand,Torben Hansen,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah B. Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald Cw Ma,Toni I. Pollin,Manjinder S. Sandhu,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Philippe Froguel,Inês Barroso,Inês Barroso,Yik-Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Paul W. Franks,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,Gil Atzmon,John C. Chambers,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E-Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Leif Groop,Gonçalo R. Abecasis,Laura J. Scott,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Hyun Min Kang,David Altshuler,David Altshuler,David Altshuler,Noël P. Burtt,Jose C. Florez,Jose C. Florez,Michael Boehnke,Mark I. McCarthy +352 more
TL;DR: The GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing and exome sequencing of 12,940 individuals of multiple ancestries as mentioned in this paper.
Posted ContentDOI
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E. Savage,Philip R. Jansen,Philip R. Jansen,Sven Stringer,Kyoko Watanabe,Julien Bryois,Christiaan de Leeuw,Mats Nagel,Swapnil Awasthi,Peter B. Barr,Jonathan R. I. Coleman,Jonathan R. I. Coleman,Katrina L. Grasby,Anke R. Hammerschlag,Jakob Kaminski,Robert Karlsson,Eva Krapohl,Max Lam,Marianne Nygaard,Chandra A. Reynolds,Joey W. Trampush,Hannah Young,Delilah Zabaneh,Sara Hägg,Narelle K. Hansell,Ida K. Karlsson,Sten Linnarsson,Grant W. Montgomery,Grant W. Montgomery,Ana B. Muñoz-Manchado,Erin Burke Quinlan,Gunter Schumann,Nathan G. Skene,Bradley T. Webb,Tonya White,Dan E. Arking,Deborah C. Koltai,Deborah C. Koltai,Dimitrios Avramopoulos,Robert M. Bilder,Panos Bitsios,Katherine E. Burdick,Katherine E. Burdick,Katherine E. Burdick,Tyrone D. Cannon,Ornit Chiba-Falek,Andrea Christoforou,Elizabeth T. Cirulli,Eliza Congdon,Aiden Corvin,Gail Davies,Ian J. Deary,Pamela DeRosse,Pamela DeRosse,Dwight Dickinson,Srdjan Djurovic,Srdjan Djurovic,Gary Donohoe,Emily Drabant Conley,Johan G. Eriksson,Thomas Espeseth,Nelson A. Freimer,Stella G. Giakoumaki,Ina Giegling,Michael Gill,David C. Glahn,Ahmad R. Hariri,Alex Hatzimanolis,Alex Hatzimanolis,Matthew C. Keller,Emma Knowles,Bettina Konte,Jari Lahti,Stephanie Le Hellard,Todd Lencz,Todd Lencz,David C. Liewald,Edythe D. London,Astri J. Lundervold,Anil K. Malhotra,Anil K. Malhotra,Ingrid Melle,Ingrid Melle,Derek W. Morris,Anna C. Need,William Ollier,Aarno Palotie,Aarno Palotie,Aarno Palotie,Antony Payton,Neil Pendleton,Russell A. Poldrack,Katri Räikkönen,Ivar Reinvang,Panos Roussos,Panos Roussos,Dan Rujescu,Fred W. Sabb,Matthew A. Scult,Olav B. Smeland,Nikolaos Smyrnis,Nikolaos Smyrnis,John M. Starr,Vidar M. Steen,Nikos C. Stefanis,Nikos C. Stefanis,Richard E. Straub,Kjetil Sundet,Aristotle N. Voineskos,Daniel R. Weinberger,Elisabeth Widen,Jin Yu,Gonçalo R. Abecasis,Ole A. Andreassen,Ole A. Andreassen,Gerome Breen,Gerome Breen,Lene Christiansen,Birgit Debrabant,Danielle M. Dick,Andreas Heinz,Jens Hjerling-Leffler,M. Arfan Ikram,Kenneth S. Kendler,Nicholas G. Martin,Sarah E. Medland,Nancy L. Pedersen,Robert Plomin,Tinca J. C. Polderman,Stephan Ripke,Stephan Ripke,Stephan Ripke,Sophie van der Sluis,Patrick Sullivan,Patrick Sullivan,Henning Tiemeier,Scott I. Vrieze,Margaret J. Wright,Danielle Posthuma +138 more
TL;DR: The largest genetic association study of intelligence to date is presented, identifying 206 genomic loci and implicating 1,041 genes (963 novel) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis.
Journal ArticleDOI
Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome
Henry Richard Johnston,Yi-Juan Hu,Jingjing Gao,Timothy D. O’Connor,Gonçalo R. Abecasis,Genevieve L. Wojcik,Christopher R. Gignoux,Pierre-Antoine Gourraud,Antoine Lizee,Mark Hansen,Rob Genuario,Dave Bullis,Cindy Lawley,Eimear E. Kenny,Eimear E. Kenny,Carlos Bustamante,Terri H. Beaty,Rasika A. Mathias,Kathleen C. Barnes,Zhaohui S. Qin +19 more
TL;DR: This array is designed based on the novel variation identified in 642 CAAPA samples of African ancestry with high coverage whole genome sequence data, and will enable better GWAS analyses for researchers with individuals of African descent in their study populations.
Journal ArticleDOI
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Goo Jun,Goo Jun,Alisa K. Manning,Marcio Almeida,Matthew Zawistowski,Andrew R. Wood,Tanya M. Teslovich,Tanya M. Teslovich,Christian Fuchsberger,Christian Fuchsberger,Shuang Feng,Pablo Cingolani,Kyle J. Gaulton,Thomas D. Dyer,Thomas W. Blackwell,Han Chen,Han Chen,Peter S. Chines,Sungkyoung Choi,Claire Churchhouse,Pierre Fontanillas,Ryan King,Sungyoung Lee,Stephen E. Lincoln,Vasily Trubetskoy,Mark A. DePristo,Tasha E. Fingerlin,Robert L. Grossman,Jason Grundstad,A. C. Heath,Jayoun Kim,Young-Jin Kim,Jason M. Laramie,Jae-Hoon Lee,Heng Li,Xuanyao Liu,Oren E. Livne,Adam E. Locke,Julian Maller,Alexander Mazur,Andrew P. Morris,Andrew P. Morris,Toni I. Pollin,Derek Ragona,David Reich,Manuel A. Rivas,Laura J. Scott,Xueling Sim,Xueling Sim,Rick Tearle,Yik Ying Teo,Yik Ying Teo,Amy L. Williams,Sebastian Zöllner,Joanne E. Curran,Juan M. Peralta,Beena Akolkar,Graeme I. Bell,Noël P. Burtt,Nancy J. Cox,Nancy J. Cox,Jose C. Florez,Jose C. Florez,Craig L. Hanis,Catherine McKeon,Karen L. Mohlke,Mark Seielstad,Mark Seielstad,James G. Wilson,Gil Atzmon,Gil Atzmon,Jennifer E. Below,Josée Dupuis,Dan L. Nicolae,Donna M. Lehman,Taesung Park,Sungho Won,Robert Sladek,David Altshuler,Mark I. McCarthy,Ravindranath Duggirala,Michael Boehnke,Timothy M. Frayling,Gonçalo R. Abecasis,John Blangero +84 more
TL;DR: The results from deep whole-genome analysis of large Mexican-American pedigrees are described, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families.