Göran Lundborg

Bio: Göran Lundborg is an academic researcher from Lund University. The author has contributed to research in topics: Sciatic nerve & Tendon. The author has an hindex of 75, co-authored 272 publications receiving 18888 citations. Previous affiliations of Göran Lundborg include Scania AB & Karolinska Institutet.

Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System

Abstract: Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells, and it promotes angiogenesis in vivo. Here we report that VEGF(165) has neurotrophic actions on cultured adult mouse superior cervical ganglia (SCG) and dorsal root ganglia (DRG), measured as axonal outgrowth. Maximal effect was observed at 10-50 ng/ml for SCG and 100 ng/ml for DRG. VEGF-induced axonal outgrowth was inhibited by the mitogen-activated protein kinase kinase inhibitor PD 98059 but not by the protein kinase inhibitor K252a. VEGF also increased survival of both neurons and satellite cells and the number of proliferating Schwann cells. Immunocytochemistry and immunoblotting revealed that VEGF was expressed in virtually all nerve cells in the SCG but only in a population of small-diameter (<35 micrometers) neurons representing approximately 30% of the neurons in DRG. Immunostaining showed that the VEGF receptor fetal liver kinase receptor (flk-1) was found on nerve cell bodies in DRG and to a lesser extent on neurons in SCG. Growth cones of regenerating axons from both types of ganglia exhibited flk-1 immunoreactivity, as did Schwann cells. We conclude that VEGF has both neurotrophic and mitogenic activity on cells in the peripheral nervous system.

The carpal tunnel syndrome. A study of carpal canal pressures.

Abstract: We measured intracarpal canal pressures with the wick catheter in fifteen patients with carpal tunnel syndrome and in twelve control subjects. The mean pressure in the carpal canal was elevated significantly in the patients. When the wrist was in neutral position, the mean pressure was thirty-two millimeters of mercury. With 90 degrees of wrist flexion the pressure increased to ninety-four millimeters of mercury, while with 90 degrees of wrist extension the mean pressure was 110 millimeters of mercury. The pressure in the control subjects with the wrist in neutral position was 2.5 millimeters of mercury; with wrist flexion the pressure rose to thirty-one millimeters of mercury, and with wrist extension it increased to thirty millimeters of mercury. Carpal tunnel release brought about an immediate and sustained reduction in pressure.

A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance.

Abstract: In spite of an enormous amount of new experimental laboratory data based on evolving neuroscientific concepts during the last 25 years peripheral nerve injuries still belong to the most challenging and difficult surgical reconstructive problems. Our understanding of biological mechanisms regulating posttraumatic nerve regeneration has increased substantially with respect to the role of neurotrophic and neurite-outgrowth promoting substances, but new molecular biological knowledge has so far gained very limited clinical applications. Techniques for clinical approximation of severed nerve ends have reached an optimal technical refinement and new concepts are needed to further increase the results from nerve repair. For bridging gaps in nerve continuity little has changed during the last 25 years. However, evolving principles for immunosuppression may open new perspectives regarding the use of nerve allografts, and various types of tissue engineering combined by bioartificial conduits may also be important. Posttraumatic functional reorganizations occurring in brain cortex are key phenomena explaining much of the inferior functional outcome following nerve repair, and increased knowledge regarding factors involved in brain plasticity may help to further improve the results. Implantation of microchips in the nervous system may provide a new interface between biology and technology and developing gene technology may introduce new possibilities in the manipulation of nerve degeneration and regeneration.

Nerve Injury and Repair

Abstract: Part 1 Cell-biological background: nerve growth axonal orientation axonal transport. Part 2 The nerve trunk: morphological basis microvascular system endoneurial fluid pressure (EFP). Part 3 Compression and stretching: biological effects of pressure classification of nerve injuries tourniquet paralysis peripheral nerve excursions stretching. Part 4 Nerve entrapment: background carpal tunnel syndrome (CTS) high median, ulnar, and radial nerve compression thoracic outlet syndrome (TOS) the "double crush syndrome" and "reversed double crush syndrome" multi-entrapments. Part 5 Nerve regeneration: the nerve cell body and proximal segment the distal segment the interstump gap the nerve chamber as an experimental tool. Part 6 Nerve repair - clinical aspects: definition of the problem timing techniques for nerve repair the microsurgical approach - mechanics versus biology epineurial versus perineurial suture techniques - an experimental approach epineurial versus perineurial suture techniques - a clinical approach factors influencing axonal growth.

Principles of Neural Science

Abstract: I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Vascular endothelial growth factor: basic science and clinical progress.

Abstract: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major inducer of VEGF gene transcription. The tyrosine kinases Flt-1 (VEGFR-1) and Flk-1/KDR (VEGFR-2) are high-affinity VEGF receptors. The role of VEGF in developmental angiogenesis is emphasized by the finding that loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF is critical also for reproductive and bone angiogenesis. Substantial evidence also implicates VEGF as a mediator of pathological angiogenesis. In situ hybridization studies demonstrate expression of VEGF mRNA in the majority of human tumors. Anti-VEGF monoclonal antibodies and other VEGF inhibitors block the growth of several tumor cell lines in nude mice. Clinical trials with various VEGF inhibitors in a variety of malignancies are ongoing. Very recently, an anti-VEGF monoclonal antibody (bevacizumab; Avastin) has been approved by the Food and Drug Administration as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy. Furthermore, VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration.