G
Gordon C. K. Roberts
Researcher at University of Leicester
Publications - 120
Citations - 6298
Gordon C. K. Roberts is an academic researcher from University of Leicester. The author has contributed to research in topics: Integrin & Dihydrofolate reductase. The author has an hindex of 50, co-authored 120 publications receiving 5989 citations.
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Journal ArticleDOI
Influence of globin structure on the state of the heme. II. Allosteric transitions in methemoglobin.
Journal ArticleDOI
RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
Benjamin T. Goult,Thomas Zacharchenko,Neil Bate,Ricky Tsang,Fiona Hey,Alexandre R. Gingras,Paul R. Elliott,Gordon C. K. Roberts,Christoph Ballestrem,David R. Critchley,Igor L. Barsukov +10 more
TL;DR: The structural characterization of the talin rod is reported, which proposes a model in which RIAM binding to R2R3 initially recruits talin to membranes where it activates integrins and recruits vinculin to stabilize the complex.
Journal ArticleDOI
Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod
Alexandre R. Gingras,Wolfgang H. Ziegler,Ronald Frank,Igor L. Barsukov,Gordon C. K. Roberts,David R. Critchley,Jonas Emsley +6 more
TL;DR: The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration and the specificity of this interaction is defined by spot-synthesizing a series of 25-mer talin VBS1 peptides containing substitutions with all the commonly occurring amino acids.
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The structure of the C-terminal actin-binding domain of talin.
Alexandre R. Gingras,Neil Bate,Benjamin T. Goult,Larnele Hazelwood,Ilona Canestrelli,J. Günter Grossmann,HongJun Liu,Nicholas S M Putz,Gordon C. K. Roberts,Niels Volkmann,Dorit Hanein,Igor L. Barsukov,David R. Critchley +12 more
TL;DR: In this article, the structure of the C-terminal actin binding domain of talin has been reported, which is a five-helix bundle linked to a Cterminal helix responsible for dimerisation.
Journal ArticleDOI
Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle
Evangelos Papagrigoriou,Alexandre R. Gingras,Igor L. Barsukov,Neil Bate,Ian J. Fillingham,Bipin Patel,Ronald Frank,Wolfgang H. Ziegler,Gordon C. K. Roberts,David R. Critchley,Jonas Emsley,Jonas Emsley +11 more
TL;DR: Activation of the VBS in talin and the recruitment of vinculin may support the maturation of small integrin/talin complexes into more stable adhesions.