Gordon H. Guyatt

TL;DR: Industry funded randomised controlled trials, in the absence of statistically significant primary outcomes, are more likely to report subgroup analyses than non-industry funded trials.

TL;DR: MAGIC as mentioned in this paper is a conceptual framework and tools to facilitate the creation, dissemination, and dynamic updating of trustworthy clinical practice guidelines, which can facilitate face-to-face shared decision-making in the clinical encounter.

TL;DR: Reporting approaches that allow investigators to use the same strategies in reporting pooled estimates from meta-analyses, even when studies use different instruments to measure the same construct will also help those developing decision aids to use quality of life data.

TL;DR: This systematic review and meta-analysis of randomized controlled trials comparing pressure and volume-limited (PVL) ventilation strategies with more traditional mechanical ventilation in adults with ALI and ARDS suggests that PVL strategies for mechanical ventilation with traditional approaches to ventilation in critically ill adults with AlI andARDS reduce mortality and are associated with increased use of paralytic agents.

TL;DR: A revised framework facilitates investigators' choice of optimal trial design, and clinicians' optimal interpretation of RCT results, by introducing two terms that refer explicitly to the purpose of a trial: A trial is mechanistic to the extent that it addresses a biological relationship and a trial is practical to the amount of comprehensive information that bears directly on specific health care decisions.