Gordon H. Guyatt

TL;DR: It is concluded that the Asthma Quality of Life Questionnaire has good measurement properties and that it is valid as both an evaluative and a discriminative instrument and should be considered for inclusion in all asthma studies.

TL;DR: Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect.

TL;DR: This article addresses GRADE's approach to determining the direction and strength of a recommendation, which describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and desirable outcomes ofinterest, confidence in the estimates ofEffect, estimates of values and preferences, and resource use.

TL;DR: An approach to classifying strength of recommendations is suggested and is directed primarily at clinicians who make treatment recommendations that they hope their colleagues will follow.