G
Gordon H. Guyatt
Researcher at McMaster University
Publications - 1749
Citations - 262329
Gordon H. Guyatt is an academic researcher from McMaster University. The author has contributed to research in topics: Randomized controlled trial & Medicine. The author has an hindex of 231, co-authored 1620 publications receiving 228631 citations. Previous affiliations of Gordon H. Guyatt include Memorial Sloan Kettering Cancer Center & Cayetano Heredia University.
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Journal ArticleDOI
Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin: an assessment of safety and pharmacodynamics: the DIRECT study.
James D. Douketis,Deborah J. Cook,Maureen O. Meade,Gordon H. Guyatt,William Geerts,Yoanna Skrobik,Martin Albert,John Granton,Paul C. Hébert,G. Pagliarello,John Marshall,Robert A. Fowler,Andreas Freitag,Christian Rabbat,David C. Anderson,Nicole Zytaruk,Diane Heels-Ansdell,Mark Crowther +17 more
TL;DR: In critically ill patients with severe renal insufficiency, DVT prophylaxis with dalteparin sodium, 5000 IU once daily, is not associated with an excessive anticoagulant effect due to drug bioaccumulation and is unlikely to contribute to bleeding.
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How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure.
TL;DR: Advice on the use of the minimal important difference (MID) is short, indeed much too short and it is advocated that dichotomizing the scores of patient-reported outcome measures facilitate interpretability of clinical trial results for those who need to understand trial results after a labelling claim has been granted.
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The fragility of statistically significant findings from randomized trials in spine surgery: a systematic survey.
Nathan Evaniew,Carly Files,Christopher A. Smith,Mohit Bhandari,Michelle Ghert,Michael Walsh,Philip J. Devereaux,Gordon H. Guyatt +7 more
TL;DR: The Fragility Index is a novel metric to inform about the robustness of statistically significant results from RCTs of spine surgery interventions and indicates that the statistical significance of a result hinges on only a few events, and a large Fragility index increases one's confidence in the observed treatment effects.
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Nosocomial pneumonia and the role of gastric pH. A meta-analysis.
TL;DR: In this article, the authors examined the differential effect of drugs used for stress ulcer prophylaxis on nosocomial pneumonia in critically ill patients, and they found that the use of sucralfate is associated with a lower incidence of nosocial pneumonia compared to agents which raise gastric pH.
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Cholestatic liver diseases and health-related quality of life.
Zobair M. Younossi,Michelle L Kiwi,Navdeep Boparai,Navdeep Boparai,Lori Lyn Price,Lori Lyn Price,Gordon H. Guyatt +6 more
TL;DR: Patients with cholestatic liver disease showed substantial impairment of HRQL, which is further affected by worsening disease severity, and patients who experienced severe itching showed profound HRQL impairment.