G
Gordon J. Lithgow
Researcher at Buck Institute for Research on Aging
Publications - 131
Citations - 11857
Gordon J. Lithgow is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 46, co-authored 122 publications receiving 10022 citations. Previous affiliations of Gordon J. Lithgow include University of Manchester & University of Colorado Boulder.
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Journal ArticleDOI
Geroscience: Linking Aging to Chronic Disease
Brian K. Kennedy,Shelley L. Berger,Anne Brunet,Judith Campisi,Judith Campisi,Ana Maria Cuervo,Elissa S. Epel,Claudio Franceschi,Gordon J. Lithgow,Richard I. Morimoto,Jeffrey E. Pessin,Thomas A. Rando,Thomas A. Rando,Arlan Richardson,Eric E. Schadt,Tony Wyss-Coray,Tony Wyss-Coray,Felipe Sierra +17 more
TL;DR: Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches, and it is critical to expand geroscience research directed at extending human healthspan.
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Extension of life-span with superoxide dismutase/catalase mimetics
Simon Melov,Joanne Ravenscroft,Sarwatt Malik,Matthew S. Gill,David W. Walker,Peter E. Clayton,Douglas C. Wallace,Bernard Malfroy,Susan R. Doctrow,Gordon J. Lithgow +9 more
TL;DR: It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.
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Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.
TL;DR: The results suggest that ability to respond to stress limits the life expectancy of C. elegans and might do so in other metazoa as well, and the relationship between increased thermotolerance and increased life-span is investigated.
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From discoveries in ageing research to therapeutics for healthy ageing
TL;DR: It is suggested that ageing research is entering a new era that has unique medical, commercial and societal implications, and that this era marks an inflection point in ageing research and for all biological research that affects the human healthspan.
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Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
TL;DR: The mechanisms by which FOXO factors contribute to longevity will be discussed in diverse animal models, from Hydra to mammals, and compelling evidence of FOXOs as contributors for extreme longevity and health span in humans will be addressed.