G
Gordon S. A. B. Stewart
Researcher at University of Nottingham
Publications - 77
Citations - 10163
Gordon S. A. B. Stewart is an academic researcher from University of Nottingham. The author has contributed to research in topics: Quorum sensing & Homoserine. The author has an hindex of 41, co-authored 77 publications receiving 9841 citations. Previous affiliations of Gordon S. A. B. Stewart include Suffolk University & Merck & Co..
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Journal ArticleDOI
Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
Kay H. McClean,Michael K. Winson,Leigh Fish,Adrian Taylor,Siri Ram Chhabra,Miguel Cámara,Mavis Daykin,John H. Lamb,Simon Swift,Barrie W. Bycroft,Gordon S. A. B. Stewart,Paul Williams +11 more
TL;DR: The ability of CV026 to respond to a series of synthetic AHL and N-acylhomocysteine thiolactone (AHT) analogues is explored, greatly extending the ability to detect a wide spectrum of AHL signal molecules.
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Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing
Michael K. Winson,Simon Swift,Leigh Fish,John P. Throup,Frieda Jørgensen,Siri Ram Chhabra,Barrie W. Bycroft,Paul Williams,Gordon S. A. B. Stewart +8 more
TL;DR: Plasmid reporter vectors have been constructed which respond to activation of LuxR and its homologues LasR and RhlR by N-acyl homoserine lactones by AHLs, allowing a comprehensive evaluation of quorum sensing signals from a test organism.
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Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.
Matthew T. G. Holden,Siri Ram Chhabra,Rocky de Nys,Paul Stead,Nigel J. Bainton,Philip J. Hill,Mike Manefield,Naresh Kumar,Maurice Labatte,Dacre England,Scott A. Rice,Michael Givskov,George P. C. Salmond,Gordon S. A. B. Stewart,Barrie W. Bycroft,Staffan Kjelleberg,Paul Williams +16 more
TL;DR: In this article, the diketopiperazines (DKPs) were found to activate the N-acylhomoserine lactone (AHL) biosensor in a concentration-dependent manner.
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Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
Amel Latifi,Michael K. Winson,Maryline Foglino,Barrie W. Bycroft,Gordon S. A. B. Stewart,Andrée Lazdunski,Paul Williams +6 more
TL;DR: PAN067 is also defective in the production of alkaline protease, haemolysin, cyanide, pyocyanin and autoinducer(s), providing clear evidence that multiple families of quorum‐sensing modulons interactively regulate gene expression in P. aeruginosa.
Journal ArticleDOI
The Pseudomonas aeruginosa Quorum-Sensing Signal Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone Has Immunomodulatory Activity
Gary Telford,David A. Wheeler,Paul Williams,P. T. Tomkins,P. Appleby,Herbert F. Sewell,Gordon S. A. B. Stewart,Barrie W. Bycroft,David I. Pritchard +8 more
TL;DR: Data indicate that OdDHL may influence the Th-1–Th-2 balance in the infected host and suggest that it may contribute to the pathogenesis of P. aeruginosa infections by functioning as a virulence determinant per se.