G
Gordon W. Duff
Researcher at University of Sheffield
Publications - 152
Citations - 19486
Gordon W. Duff is an academic researcher from University of Sheffield. The author has contributed to research in topics: Interleukin & Interleukin 1 receptor antagonist. The author has an hindex of 66, co-authored 151 publications receiving 19018 citations. Previous affiliations of Gordon W. Duff include Lund University & University of Edinburgh.
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Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
TL;DR: It is demonstrated, with reporter genes under the control of the two allelic TNF promoters, that TNF2 is a much stronger transcriptional activator than the common allele (TNF1) in a human B cell line.
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The interleukin-1 genotype as a severity factor in adult periodontal disease
Kenneth S. Kornman,Allison Crane,Hwa-Ying Wang,Francesco S.di Giovlne,Michael G. Newman,Frederick W. Pirk,Thomas G. Wilson,Frank L. Higginbottom,Gordon W. Duff +8 more
TL;DR: It is demonstrated that specific genetic markers, that have been associated with increased IL-1 production, are a strong indicator of susceptibility to severe periodontitis in adults.
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Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product.
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An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.
Anthony G. Wilson,N. de Vries,Flemming Pociot,F. S. Di Giovine,L. B. A. Van Der Putte,Gordon W. Duff +5 more
TL;DR: Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles.
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Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat
Joanna K. Tarlow,Alexandra I. F. Blakemore,Andrew Lennard,Roberto Solari,Howard N. Hughes,Alexander Steinkasserer,Gordon W. Duff +6 more
TL;DR: The polymorphism in intron 2 of the interleukin-1 receptor antagonist gene is investigated and two new alleles of the system are identified and the variable copy number of an 86-bp sequence may have functional significance.