Gordon X. Wang

TL;DR: A novel role for astrocytes in mediating synapse elimination in the developing and adult brain is revealed, MEGF10 and MERTK are identified as critical proteins in the synapse remodelling underlying neural circuit refinement, and have important implications for understanding learning and memory as well as neurological disease processes.

TL;DR: Glypicans is identified as a family of novel astrocyte-derived molecules that are necessary and sufficient to promote glutamate receptor clustering and receptivity and to induce the formation of postsynaptically functioning CNS synapses.

TL;DR: TRPC currents reflect early events in the growth cone's detection of some extracellular guidance signals, resulting in membrane depolarization and cytoplasmic Ca2+ elevation that mediates the turning of growth cones.

TL;DR: Time-lapse two-photon imaging of the presynaptic marker synaptophysin in hypocretin/orexin neurons is used to determine the dynamics of synaptic modifications during the day and night and provides real-time in vivo evidence of circadian and homeostatic regulation of structural synaptic plasticity.

TL;DR: The results demonstrate the existence of a functional HCRT neurons-pineal gland circuit able to modulate melatonin production and sleep consolidation and indicate that H CRT can modulatemelatonin production at night.