Graeme Sargent

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Results suggest that NBR1 is the specific autophagy receptor for pexophagy, and that substrate selectivity is partly achieved by N BR1 itself by coincident binding of the J and UBA domains to peroxisomes.

TL;DR: The E3 ubiquitin ligase PEX2 is identified as the causative agent of mammalian pexophagy during amino acid starvation, and expression increases to ubiquitinate peroxisomal membrane proteins and signalperoxisome degradation by autophagy.