抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Preface to the Princeton Landmarks in Biology Edition vii Preface xi Symbols Used xiii 1. The Importance of Islands 3 2. Area and Number of Speicies 8 3. Further Explanations of the Area-Diversity Pattern 19 4. The Strategy of Colonization 68 5. Invasibility and the Variable Niche 94 6. Stepping Stones and Biotic Exchange 123 7. Evolutionary Changes Following Colonization 145 8. Prospect 181 Glossary 185 References 193 Index 201

The Theory of Island Biogeography

Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

So far in this course we have dealt entirely with the evolution of characters that are controlled by simple Mendelian inheritance at a single locus. There are notes on the course website about gametic disequilibrium and how allele frequencies change at two loci simultaneously, but we didn’t discuss them. In every example we’ve considered we’ve imagined that we could understand something about evolution by examining the evolution of a single gene. That’s the domain of classical population genetics. For the next few weeks we’re going to be exploring a field that’s actually older than classical population genetics, although the approach we’ll be taking to it involves the use of population genetic machinery. If you know a little about the history of evolutionary biology, you may know that after the rediscovery of Mendel’s work in 1900 there was a heated debate between the “biometricians” (e.g., Galton and Pearson) and the “Mendelians” (e.g., de Vries, Correns, Bateson, and Morgan). Biometricians asserted that the really important variation in evolution didn’t follow Mendelian rules. Height, weight, skin color, and similar traits seemed to

Human biochemical genetics

Soil Chemical Analysis

A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.

https://science.sciencemag.org/content/sci/303/5659/808.full.pdf

Global Mapping of the Yeast Genetic Interaction Network

Originally published in 1982, The Masterpiece of Nature examines sex as representative of the most important challenge to the modern theory of evolution. The book suggests that sex evolved, not as the result of normal Darwinian processes of natural selection, but through competition between populations or species - a hypothesis elsewhere almost universally discredited. The book also discusses the nature of sex and its consequences for the individual and for the population, as well as various other theories of sex. Since the value of these theories is held to reside wholly in their ability to predict the patterns of sexuality observed in nature, the book seeks to provide an extensive review of the circumstances in which sexuality is attenuated or lost throughout the animal kingdom, and these facts are then used to weigh up the merits of the rival theories. This book will be of interest to researchers in the area of genetics, ecology and evolutionary biology.

The Masterpiece of Nature: The Evolution and Genetics of Sexuality

The main methodological problem of comparative biology is to distinguish between effects attributable to ancestry and those attributable to function. The nested analysis of variance addresses this problem by partitioning variance and covariance between taxonomic levels. The estimation of variance components and the derived intraclass correlation coefficient can be used to describe the overall increase in variation through time and the relation between variances at different taxonomic levels. Applying this procedure to data about the body mass of eutherian mammals showed a steep increase in variance associated with the adaptive radiation of the group in early Tertiary times, with much lower rates of increase thereafter; chromosome number showed a similar but shallower increase, implying that chromosome number varies more between taxa at lower levels of classification than does body mass. The variance of species within genera increased with the geologic age of the genus, permitting a quantitative descriptio...

A Comparative Method

A Big Book on Sex@@@The Masterpiece of Nature: The Evolution and Genetics of Sexuality.

This paper identifies the effects of different types of reproductive cost on the pattern of life histories. By reproductive cost I mean the generally deleterious effect of present reproduction on f...

Graham Bell

Papers

Global Mapping of the Yeast Genetic Interaction Network

The Masterpiece of Nature: The Evolution and Genetics of Sexuality

A Comparative Method

A Big Book on Sex@@@The Masterpiece of Nature: The Evolution and Genetics of Sexuality.

The Costs of Reproduction and Their Consequences