G
Graham F. Hatfull
Researcher at University of Pittsburgh
Publications - 306
Citations - 24864
Graham F. Hatfull is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Genome & Bacteriophage. The author has an hindex of 77, co-authored 281 publications receiving 21606 citations. Previous affiliations of Graham F. Hatfull include Albert Einstein College of Medicine & Howard Hughes Medical Institute.
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Journal ArticleDOI
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
R. Baer,R. Baer,Alan T. Bankier,Mark D. Biggin,Prescott L. Deininger,Paul J. Farrell,Toby J. Gibson,Graham F. Hatfull,Graham S. Hudson,Sandra C. Satchwell,C. Séguin,C. Séguin,P. S. Tuffnell,Bart Barrell +13 more
TL;DR: The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure.
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New use of BCG for recombinant vaccines.
Charles K. Stover,V F de la Cruz,Thomas R. Fuerst,Jeanne E. Burlein,L. A. Benson,L. T. Bennett,Geetha P. Bansal,J. F. Young,Mong Hong Lee,Graham F. Hatfull,Scott B. Snapper,Raúl G. Barletta,William R. Jacobs,Barry R. Bloom +13 more
TL;DR: Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed and can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
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Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage
TL;DR: DNA and predicted protein sequence similarities, implying homology, are reported, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria, suggesting common ancestry among these phage genes.
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Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus
Rebekah M. Dedrick,Carlos A Guerrero-Bustamante,Rebecca A. Garlena,Daniel A. Russell,Katrina Ford,Kathryn A. Harris,Kimberly Gilmour,James Soothill,Deborah Jacobs-Sera,Robert T. Schooley,Graham F. Hatfull,Helen Spencer +11 more
TL;DR: Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
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Origins of Highly Mosaic Mycobacteriophage Genomes
Marisa L. Pedulla,Michael E. Ford,Jennifer M. Houtz,Tharun Karthikeyan,Curtis Wadsworth,John A. Lewis,Debbie Jacobs-Sera,Jacob Falbo,Joseph Gross,Nicholas R. Pannunzio,William J. Brucker,Vanaja Kumar,Jayasankar Kandasamy,Lauren Keenan,Svetoslav Bardarov,Jordan Kriakov,Jeffrey G. Lawrence,William R. Jacobs,Roger W. Hendrix,Graham F. Hatfull +19 more
TL;DR: The genomic sequences of ten newly isolated mycobacteriophages suggest that the bacteriophage population as a whole is amazingly diverse and may represent the largest unexplored reservoir of sequence information in the biosphere.