G
Grasiele Sausen
Researcher at Brigham and Women's Hospital
Publications - 4
Citations - 41
Grasiele Sausen is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Mutation (genetic algorithm) & Endothelial stem cell. The author has an hindex of 1, co-authored 4 publications receiving 10 citations.
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Journal ArticleDOI
Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity.
Roberto Molinaro,Roberto Molinaro,Mi Kyung Yu,Grasiele Sausen,Colette A. Bichsel,Claudia Corbo,Claudia Corbo,Eduardo J. Folco,Gha Young Lee,Yuan Liu,Yevgenia Tesmenitsky,Eugenia Shvartz,Galina K. Sukhova,Frederik Kloss,Kevin Croce,Omid C. Farokhzad,Jinjun Shi,Peter Libby +17 more
TL;DR: In this paper, Collagen IV-targeted nanoparticles (Col IV NP) were used to deliver PAD4 inhibitors selectively to regions of endothelial cell sloughing and collagen IV-rich basement membrane exposure.
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A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor.
Huaner Ni,Huaner Ni,Stefan Haemmig,Yihuan Deng,Jingshu Chen,Viorel Simion,Dafeng Yang,Galina K. Sukhova,Eugenia Shvartz,A.K.M. Khyrul Wara,Henry S. Cheng,Daniel Pérez-Cremades,Carmel Assa,Grasiele Sausen,Rulin Zhuang,Qiuyan Dai,Mark W. Feinberg +16 more
TL;DR: In this paper, a cardiac mesoderm enhancer-associated noncoding RNA (CARMN) was identified as a critical regulator of vascular smooth muscle cell (VSMC) plasticity and atherosclerosis.
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Abstract 15355: Interleukin-1beta Inhibition Attenuates Accelerated Atherosclerosis in Mice With Tet2 Loss of Function in a Sex-dependent Fashion
Amelie Vromman,Shamsudheen K. Vellarikkal,M. J. Gomes,Victoria Ruvkun,Eugenia Shvartz,Eva Kritikou,Paul Carter,Samuel D. Moscavitch,Tetsushi Nakao,Rob S. Sellar,Marie McConkey,Grasiele Sausen,Waihay J. Wong,Yevgenia Tesmenitsky,Shah Kavi,Andrew H. Lichtman,Benjamin L. Ebert,Galina K. Sukhova,Rajat M. Gupta,Peter Libby +19 more
TL;DR: This unexpected sex-dependence of accelerated atherogenesis in Tet2 - /- bone-marrow mice on IL-1β signaling lays the ground for further mechanistic exploration.
Journal ArticleDOI
Abstract 15575: The Clonal Hematopoiesis Mutation Jak2 V617F Aggravates NETosis and Endothelial Injury in Mouse Arteries With Erosion-like Intimas
Roberto Molinaro,Rob S. Sellar,Grasiele Sausen,Amelie Vromman,Eduardo J. Folco,Galina K. Sukhova,Benjamin L. Ebert,Peter Libby +7 more
TL;DR: Rux treatment mitigated the adverse effects of Jak2 V617F on both NET accumulation and endothelial integrity, supporting the translational potential of these observations in individuals with clonal hematopoiesis due to Jak1,2 inhibitor, ruxolitinib (Rux).