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Graziele L. Novais

Bio: Graziele L. Novais is an academic researcher from University of São Paulo. The author has contributed to research in topics: Diazo. The author has an hindex of 1, co-authored 1 publications receiving 15 citations.
Topics: Diazo

Papers
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Journal ArticleDOI
TL;DR: In this paper, the traditional methods to prepare diazocarbonyl compounds as well as the new methods and recent improvements in experimental procedures are summarized and compared. And the emergence of continuous flow techniques has allowed safer and environmentally friendly procedures for handling diazomethane and diazo compounds and will also be a topic in this review.
Abstract: For many years diazocarbonyl compounds have been studied due to their versatility and usability in many chemical transformations. In this review, we summarize the traditional methods to prepare these compounds as well as the new methods and recent improvements in experimental procedures. Moreover, emergence of continuous flow techniques has allowed safer and environmentally friendly procedures for the handling of diazomethane and diazo compounds and will also be a topic in this review

21 citations


Cited by
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Journal ArticleDOI
TL;DR: Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 to provide 2-substituted indoles in just one step.
Abstract: Imidoyl sulfoxonium ylides are presented for the first time as potential precursors to generate α-imino metal-carbene intermediates and applied in direct C-H functionalization reactions catalyzed by [Ir(cod)Cl]2 (4 mol %) to provide 2-substituted indoles (up to 70% yield) in just one step. This class of sulfur ylide is successfully obtained from imidoyl chloride and dimethylsulfoxonium methylide (23 new examples in 45-85% yield) or by imino group formation from the corresponding β-keto sulfoxonium ylides and anilines in the presence of TiCl4 as a Lewis acid (9 examples in 33-94% yield).

36 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used eco-friendly silica-supported HClO4 as the catalyst for solvent-free O-H insertion reactions in the presence of diazo carbonyl compounds.

24 citations

Journal ArticleDOI
TL;DR: Through this method, the successive site-selective conjugation of the triazido molecule with three different components is demonstrated and the selective conversion of alkyl azido groups at the carbonyl α-position to diazo compounds is reported.
Abstract: This paper reports on the selective conversion of alkyl azido groups at the carbonyl α-position to diazo compounds. Through β-elimination of dinitrogen, followed by hydrazone formation/decomposition, α-azidocarbonyl moieties were transformed into α-diazo carbonyl groups in one step. As these reaction conditions do not involve aryl or general alkyl azides, site-selective conversions of di- and triazides were achieved. Through this method, the successive site-selective conjugation of the triazido molecule with three different components is demonstrated.

20 citations

Journal ArticleDOI
TL;DR: An efficient cascade approach to thiosubstituted benzoxazoles has been developed and features very good functional group tolerance and is applicable to substrates with different electronic properties.
Abstract: An efficient cascade approach to thiosubstituted benzoxazoles has been developed. The transformation starts with in situ generation of a diazo compound via annulation-triggered electrocyclic openin...

14 citations

Journal ArticleDOI
03 Jan 2019
TL;DR: A direct synthesis of the rare fused bicyclic [1,2,3]-triazoles is demonstrated, employing γ-N-protected amino diazoketones as useful synthetic platforms and carried out in good to excellent yields.
Abstract: Triazoles are an important class of N-heterocycles that are well known for their broad biological activities. In this work, we would like to demonstrate a direct synthesis of the rare fused bicyclic [1,2,3]-triazoles, employing γ-N-protected amino diazoketones as useful synthetic platforms. The strategy was based on the deprotection of a trifluoroacetamide group for the intramolecular and in situ generation of an α-diazo imine intermediate, followed by a 5-endo-dig cyclization to construct the bicyclic unit. In this fashion, the synthesis of a series of fused bicyclic [1,2,3]-triazoles could be carried out in good to excellent yields (63–95%).

9 citations