G
Graziella Migliorati
Researcher at University of Perugia
Publications - 152
Citations - 10517
Graziella Migliorati is an academic researcher from University of Perugia. The author has contributed to research in topics: Apoptosis & Natural killer cell. The author has an hindex of 36, co-authored 148 publications receiving 9964 citations. Previous affiliations of Graziella Migliorati include University of Messina & Sapienza University of Rome.
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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
TL;DR: A flow cytometric method for measuring the percentage of apoptotic nuclei after propidium iodide staining in hypotonic buffer is developed and shown an excellent correlation with the results obtained with both electrophoretic and colorimetric methods.
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A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death.
F. D'Adamio,Ornella Zollo,R. Moraca,Emira Ayroldi,Stefano Bruscoli,Andrea Bartoli,Lorenza Cannarile,Graziella Migliorati,Carlo Riccardi +8 more
TL;DR: GILZ expression selectively protects T cells from apoptosis induced by treatment with anti-CD3 monoclonal antibody but not by treatment of other apoptotic stimuli, and correlates with inhibition of Fas and Fas ligand expression.
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A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.
Giuseppe Nocentini,Linda Giunchi,Simona Ronchetti,Ludovic Tibor Krausz,Andrea Bartoli,R. Moraca,Graziella Migliorati,Carlo Riccardi +7 more
TL;DR: GITR is a new member of tumor necrosis factor/nerve growth factor receptor family involved in the regulation of T cell receptor-mediated cell death.
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Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor κB
Emira Ayroldi,Graziella Migliorati,Stefano Bruscoli,Cristina Marchetti,Ornella Zollo,Lorenza Cannarile,F. D'Adamio,Carlo Riccardi +7 more
TL;DR: A new molecular mechanism involved in the dexamethasone-induced regulation of NF-kappaB activity and T-cell activation is identified and is identified as GILZ-mediated modulation of TCR-induced responses.
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Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10
Dominique Berrebi,Stefano Bruscoli,Stefano Bruscoli,Nicolas Cohen,Nicolas Cohen,Arnaud Foussat,Arnaud Foussat,Graziella Migliorati,Graziella Migliorati,Laurence Bouchet-Delbos,Laurence Bouchet-Delbos,Marie-Christine Maillot,Marie-Christine Maillot,Alain Portier,Alain Portier,Jacques Couderc,Jacques Couderc,Pierre Galanaud,Pierre Galanaud,Michel Peuchmaur,Michel Peuchmaur,Carlo Riccardi,Carlo Riccardi,Dominique Emilie,Dominique Emilie +24 more
TL;DR: It is found that GILZ was constitutively produced by macrophages in nonlymphoid tissues of humans and mice and appears to play a key role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL-10.