Grazyna Biala

TL;DR: The neurobiology and methodological modifications of the test commonly used in behavioral pharmacology are reviewed to review the novel object recognition paradigms in animals, as a valuable measure of cognition.

TL;DR: Results demonstrate that imperatorin may offer protection against scopolamine-induced memory impairments and possesses antioxidant properties, thus after further preclinical and clinical studies this compound may provide an interesting approach in pharmacotherapy, as well as prophylactics of AD.

TL;DR: The results suggest that the rewarding properties of ethanol could be, at least in part, due to its action at the NMDA receptor complex, which can be useful in the treatment of ethanol dependence.

TL;DR: The hypothesis that similar neural calcium-dependent mechanisms are involved in nicotine- and morphine-induced reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats is supported, and the conditioned place preference paradigm appears to be a useful tool for studies of the relapse of drug-seeking behaviour in laboratory animals.

TL;DR: The experiments indicated that repeated administration of nociceptin at increasing doses during conditioning significantly attenuated the reinforcing effect of amphetamine in conditioned place preference paradigm, suggesting the involvement of nOCiceptin in long-lasting neuronal adaptation after repeated amphetamine treatment.