G
Gregory Gimenez
Researcher at University of Otago
Publications - 67
Citations - 3228
Gregory Gimenez is an academic researcher from University of Otago. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 23, co-authored 56 publications receiving 2740 citations. Previous affiliations of Gregory Gimenez include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Microbial culturomics: paradigm shift in the human gut microbiome study
Jean-Christophe Lagier,Fabrice Armougom,Matthieu Million,Perrine Hugon,Isabelle Pagnier,Catherine Robert,Fadi Bittar,Ghislain Fournous,Gregory Gimenez,Marie Maraninchi,Jean-François Trape,Eugene V. Koonin,B. La Scola,Didier Raoult +13 more
TL;DR: Culturomics complements metagenomics by overcoming the depth bias inherent in metagenomic approaches, and identifies 174 species never described previously in the human gut.
Journal ArticleDOI
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling
Mike Clarke,Amanda J. Lohan,Bernard A. Liu,Ilias Lagkouvardos,Scott William Roy,Nikhat Zafar,Claire Bertelli,Christina Schilde,Arash Kianianmomeni,Thomas R. Bürglin,Christian Frech,Bernard Turcotte,Klaus O. Kopec,John M. Synnott,Caleb Choo,Ivan A. Paponov,Aliza Finkler,Chris Soon Heng Tan,Andrew P. Hutchins,Thomas Weinmeier,Thomas Rattei,Jeffery Sc Chu,Gregory Gimenez,Manuel Irimia,Daniel J. Rigden,David A. Fitzpatrick,Jacob Lorenzo-Morales,Alex Bateman,Cheng-Hsun Chiu,Petrus Tang,Peter Hegemann,Hillel Fromm,Didier Raoult,Gilbert Greub,Diego Miranda-Saavedra,Nansheng Chen,Piers Nash,Michael L. Ginger,Matthias Horn,Pauline Schaap,Lis Caler,Brendan J. Loftus +41 more
TL;DR: In this paper, the authors present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary freeliving amoebozoan.
Journal ArticleDOI
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Erinn Soucie,Ziming Weng,Laufey Geirsdóttir,Laufey Geirsdóttir,Laufey Geirsdóttir,Kaaweh Molawi,Julien Maurizio,Julien Maurizio,Julien Maurizio,Romain Fenouil,Romain Fenouil,Romain Fenouil,Noushine Mossadegh-Keller,Noushine Mossadegh-Keller,Noushine Mossadegh-Keller,Gregory Gimenez,Gregory Gimenez,Gregory Gimenez,Laurent Vanhille,Laurent Vanhille,Laurent Vanhille,Meryam Beniazza,Meryam Beniazza,Meryam Beniazza,Jeremy Favret,Jeremy Favret,Jeremy Favret,Carole Berruyer,Carole Berruyer,Carole Berruyer,Pierre Perrin,Pierre Perrin,Pierre Perrin,Nir Hacohen,Jean-Christophe Andrau,Pierre Ferrier,Pierre Ferrier,Pierre Ferrier,Patrice Dubreuil,Arend Sidow,Michael H. Sieweke +40 more
TL;DR: It is reported that in macrophages at homeostasis, a pair of transcription factors (MafB and c-Maf) bind to and repress the enhancers of genes regulating self-renewal, and how these mechanisms activate macrophage self-Renewal under homeostatic and challenge conditions in vivo is investigated.
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C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells
Bérengère de Laval,Julien Maurizio,Prashanth K. Kandalla,Prashanth K. Kandalla,Gabriel Brisou,Louise Simonnet,Caroline Huber,Gregory Gimenez,Orit Matcovitch-Natan,Susanne Reinhardt,Eyal David,Alexander Mildner,Achim Leutz,Bertrand Nadel,Christophe Bordi,Ido Amit,Sandrine Sarrazin,Michael H. Sieweke,Michael H. Sieweke +18 more
TL;DR: Short-term immune signaling can induce C/EBPβ-dependent chromatin accessibility, resulting in HSC-trained immunity, during secondary infection, establishing a mechanism for how infection history can be epigenetically inscribed in H SC as an integral memory function of innate immunity.
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Phylogenetic and Phyletic Studies of Informational Genes in Genomes Highlight Existence of a 4th Domain of Life Including Giant Viruses
TL;DR: A single common origin is reported for Nucleocytoplasmic Large DNA Viruses (NCLDV), DNA processing genes rooted between Archaea and Eukarya, with a topology congruent with that of the ribosomal tree, and it is hypothesized that the core genome of NCLDVs is as ancient as the three currently accepted domains of life.