G
Gregory L. Stahl
Researcher at Brigham and Women's Hospital
Publications - 182
Citations - 12151
Gregory L. Stahl is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Complement system & Mannan-binding lectin. The author has an hindex of 60, co-authored 178 publications receiving 11418 citations. Previous affiliations of Gregory L. Stahl include Thorn & Osaka University.
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Journal ArticleDOI
Predominant role for C5b-9 in renal ischemia/reperfusion injury
Wuding Zhou,Conrad A. Farrar,Katsushige Abe,Julian R. Pratt,James Marsh,Yi Wang,Gregory L. Stahl,Steven H. Sacks +7 more
TL;DR: The membrane attack complex of complement (in which C5 and C6 participate) may account for the effect of complement on mouse renal I/R injury and is a potential target for prevention of I-R injury in this model.
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Myocardial Infarction and Apoptosis After Myocardial Ischemia and Reperfusion Role of the Terminal Complement Components and Inhibition by Anti-C5 Therapy
TL;DR: Anti-C5 therapy in the setting of MI/R significantly inhibits cell apoptosis, necrosis, and PMN infiltration in the rat despite C3 deposition.
Journal ArticleDOI
Human IgA Activates the Complement System via the Mannan-Binding Lectin Pathway
Anja Roos,Lee H. Bouwman,van Gijlswijk-Janssen Dj,Maria C. Faber-Krol,Gregory L. Stahl,Mohamed R. Daha +5 more
TL;DR: MBL binding to IgA results in complement activation, which is proposed to lead to a synergistic action of MBL and IgA in antimicrobial defense, and may explain glomerular complement deposition in IgA nephropathy.
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Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators
Charles N. Serhan,Ashish Jain,Sylvie Marleau,Clary B. Clish,Alpdogan Kantarci,Balsam Behbehani,Sean P. Colgan,Gregory L. Stahl,Aksam Merched,Nicos A. Petasis,Lawrence Chan,Thomas E. Van Dyke +11 more
TL;DR: Results indicate that overexpression of 15-LO type I and LXA4 is associated with dampened PMN-mediated tissue degradation and bone loss, suggesting that enhanced anti-inflammation status is an active process, and suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis.
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Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease.
Anja Roos,Maria Pia Rastaldi,Novella Calvaresi,Beatrijs Oortwijn,N. Schlagwein,Daniëlle J. van Gijlswijk-Janssen,Gregory L. Stahl,Misao Matsushita,Teizo Fujita,Cees van Kooten,Mohamed R. Daha +10 more
TL;DR: Findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease.