G
Gregory Lacraz
Researcher at Université de Sherbrooke
Publications - 17
Citations - 636
Gregory Lacraz is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Type 2 diabetes & Islet. The author has an hindex of 11, co-authored 16 publications receiving 520 citations. Previous affiliations of Gregory Lacraz include Paris Diderot University & Utrecht University.
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Journal ArticleDOI
The GK rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?
Bernard Portha,Gregory Lacraz,Micheline Kergoat,Françoise Homo-Delarche,M.H. Giroix,D. Bailbé,M. N. Gangnerau,M. Dolz,Cécile Tourrel-Cuzin,Jamileh Movassat +9 more
TL;DR: This review is aimed to illustrate to what extend the Goto-Kakizaki rat, one of the best characterized animal models of spontaneous T2D, has proved be a valuable tool offering sufficient commonalities to study these aspects.
Journal ArticleDOI
Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity
Gregory Lacraz,André-Jean Rouleau,Vanessa Couture,Thomas Söllrald,Geneviève Drouin,Noémie Veillette,Michel Grandbois,Guillaume Grenier +7 more
TL;DR: Findings provide novel evidence that the low regenerative potential of aged skeletal muscle is independent of intrinsic MPC properties but is related to the increase in the stiffness of the MPC microenvironment.
Journal ArticleDOI
Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive Up-Regulation of Their Antioxidant Defenses
Gregory Lacraz,Florence Figeac,Jamileh Movassat,Nadim Kassis,Josiane Coulaud,Anne Galinier,Corinne Leloup,D. Bailbé,Françoise Homo-Delarche,Bernard Portha +9 more
TL;DR: The GK/Par model illustrates the effectiveness of adaptive response to OS by β-cells to achieve self-tolerance, and shows that such a phenotype was not innate but spontaneously acquired after diabetes onset, as the result of an adaptiveresponse to the diabetic environment.
Journal ArticleDOI
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
Gregory Lacraz,M.H. Giroix,Nadim Kassis,Josiane Coulaud,Anne Galinier,Christophe Noll,Mélanie Cornut,Fabien Schmidlin,Jean-Louis Paul,Nathalie Janel,Jean-Claude Irminger,Micheline Kergoat,Bernard Portha,Marc Y. Donath,Jan A. Ehses,Françoise Homo-Delarche +15 more
TL;DR: GK rat islets have increased mRNA expression of markers of early islet endothelial cell activation, possibly triggered by several metabolic factors, and also some defense mechanisms, which highlights a major endothelial-related role for IL-1 in GK islet alterations.
Journal ArticleDOI
Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease
Yuneivy Cepero-Donates,Gregory Lacraz,Gregory Lacraz,Farnaz Ghobadi,Volatiana Rakotoarivelo,Sakina Orkhis,Marian Mayhue,Yi-Guang Chen,Marek Rola-Pleszczynski,Alfredo Menendez,Subburaj Ilangumaran,Sheela Ramanathan +11 more
TL;DR: It is shown that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.