G
Gregory LaMonte
Researcher at University of California, San Diego
Publications - 26
Citations - 1309
Gregory LaMonte is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Plasmodium falciparum & Proteasome. The author has an hindex of 13, co-authored 23 publications receiving 995 citations. Previous affiliations of Gregory LaMonte include Durham University & Duke University.
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Journal ArticleDOI
Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance
Gregory LaMonte,Nisha Philip,Joseph M. Reardon,Joshua R. Lacsina,William H. Majoros,Lesley Chapman,Courtney D. Thornburg,Marilyn J. Telen,Uwe Ohler,Christopher V. Nicchitta,Timothy A.J. Haystead,Jen-Tsan Chi +11 more
TL;DR: Sickle cell erythrocytes exhibit cell-intrinsic resistance to malaria in part through an atypical miRNA activity, which may represent a unique host defense strategy against complex eukaryotic pathogens.
Journal ArticleDOI
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Annie N. Cowell,Eva S. Istvan,Amanda K. Lukens,Amanda K. Lukens,Maria G. Gomez-Lorenzo,Manu Vanaerschot,Tomoyo Sakata-Kato,Erika L. Flannery,Pamela Magistrado,Edward Owen,Matthew Abraham,Gregory LaMonte,Heather J. Painter,Roy Williams,Virginia Franco,María Linares,Ignacio Arriaga,Selina Bopp,Victoria C. Corey,Nina F. Gnädig,Olivia Coburn-Flynn,Christin Reimer,Purva Gupta,James M. Murithi,Pedro A. Moura,Olivia Fuchs,Erika Sasaki,Sang W. Kim,Christine H. Teng,Lawrence T. Wang,Aslı Akidil,Sophie H. Adjalley,Paul Willis,Dionicio Siegel,Olga Tanaseichuk,Yang Zhong,Yingyao Zhou,Manuel Llinás,Sabine Ottilie,Francisco-Javier Gamo,Marcus C. S. Lee,Marcus C. S. Lee,Daniel E. Goldberg,David A. Fidock,Dyann F. Wirth,Dyann F. Wirth,Elizabeth A. Winzeler,Elizabeth A. Winzeler +47 more
TL;DR: Genome sequencing elucidates potential drug resistance in the malaria parasite and identifies antimalarial targets and drug-resistance genes, as well as discovering hitherto unrecognized drug target–inhibitor pairs.
Journal ArticleDOI
Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
Gregory LaMonte,Xiaohu Tang,Julia Ling-Yu Chen,Jianli Wu,Chien-Kuang Cornelia Ding,Chien-Kuang Cornelia Ding,Melissa M. Keenan,Carolyn Sangokoya,Hsiu-Ni Kung,Hsiu-Ni Kung,Olga Ilkayeva,Laszlo G. Boros,Christopher B. Newgard,Christopher B. Newgard,Jen-Tsan Chi +14 more
TL;DR: In this paper, stable isotope tracers were used to examine how acidosis impacts glucose, glutamine, and palmitate metabolism in breast cancer cells exposed to extracellular acidosis.
Journal ArticleDOI
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
Shang Ma,Stuart M. Cahalan,Gregory LaMonte,Nathan D. Grubaugh,Wei-Zheng Zeng,Swetha E. Murthy,Emma Paytas,Ramya Gamini,Viktor Lukacs,Tess Whitwam,Meaghan Loud,Rakhee Lohia,Laurence Berry,Shahid M. Khan,Chris J. Janse,Michael Bandell,Christian Schmedt,Kai Wengelnik,Andrew I. Su,Eric Honoré,Elizabeth A. Winzeler,Kristian G. Andersen,Ardem Patapoutian +22 more
TL;DR: A mouse model of hereditary xerocytosis is engineered and it is shown that Plasmodium infection fails to cause experimental cerebral malaria in these mice due to the action of Piezo1 in RBCs and in T cells.
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A Quantitative Trait Locus (LSq-1) on Mouse Chromosome 7 Is Linked to the Absence of Tissue Loss After Surgical Hindlimb Ischemia
Ayotunde O. Dokun,Sehoon Keum,Surovi Hazarika,Yongjun Li,Gregory LaMonte,Ferrin C. Wheeler,Douglas A. Marchuk,Brian H. Annex +7 more
TL;DR: A quantitative trait locus on murine chromosome 7 (LSq-1) that is associated with the absence of tissue loss in a preclinical model of PAD is identified and may be useful in identifying gene(s) that influence PAD in humans.