G
Gregory M. Cole
Researcher at University of California, Los Angeles
Publications - 47
Citations - 6038
Gregory M. Cole is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Alzheimer's disease & Synaptosome. The author has an hindex of 29, co-authored 47 publications receiving 5497 citations. Previous affiliations of Gregory M. Cole include Veterans Health Administration & University of California.
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Journal ArticleDOI
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Fusheng Yang,Giselle P. Lim,Giselle P. Lim,Aynun N. Begum,Aynun N. Begum,Oliver J. Ubeda,Oliver J. Ubeda,Mychica Simmons,Mychica Simmons,Surendra S. Ambegaokar,Surendra S. Ambegaokar,Pingping P. Chen,Pingping P. Chen,Rakez Kayed,Charles G. Glabe,Sally A. Frautschy,Sally A. Frautschy,Gregory M. Cole,Gregory M. Cole +18 more
TL;DR: It is suggested that low dose curcumin effectively disaggregates Aβ as well as prevents fibril and oligomer formation, supporting the rationale forCurcumin use in clinical trials preventing or treating AD.
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Alzheimer's disease Etiologies, pathophysiology, cognitive reserve, and treatment opportunities
TL;DR: Advances in understanding the pathogenetic cascade of events that characterize AD provide a framework for early detection and therapeutic interventions, including transmitter replacement therapies, antioxidants, anti-inflammatory agents, estrogens, nerve growth factor, and drugs that prevent amyloid formation in the brain.
Journal ArticleDOI
A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease
TL;DR: A study of curcumin in patients with AD is performed to gather information on the bioavailability, safety and tolerability of this promising agent in the treatment and/or prevention of AD.
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Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease
Yosef Koronyo,David Biggs,Ernesto Barron,David S. Boyer,Joel A. Pearlman,William Au,Shawn Kile,Austin Blanco,Dieu-Trang Fuchs,Adeel Ashfaq,Sally A. Frautschy,Gregory M. Cole,Carol A. Miller,David R. Hinton,Steven Verdooner,Keith L. Black,Maya Koronyo-Hamaoui +16 more
TL;DR: The geometric distribution and increased burden of retinal amyloid pathology in AD, together with the feasibility to noninvasively detect discrete retinalAmyloid deposits in living patients, may lead to a practical approach for large-scale AD diagnosis and monitoring.
Journal ArticleDOI
Synaptic Changes in Alzheimer's Disease: Increased Amyloid-β and Gliosis in Surviving Terminals Is Accompanied by Decreased PSD-95 Fluorescence
Karen H. Gylys,Jeffrey A. Fein,Fusheng Yang,Dorothy J. Wiley,Carol A. Miller,Gregory M. Cole +5 more
TL;DR: The results suggest that synapse-associated amyloid-beta is prominent in regions relatively unaffected by AD lesions, and that amyloids accumulation in surviving terminals is accompanied by gliosis and alteration in the postsynaptic structure.