G
Gregory S. Korbutt
Researcher at University of Alberta
Publications - 186
Citations - 17945
Gregory S. Korbutt is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 48, co-authored 175 publications receiving 17043 citations. Previous affiliations of Gregory S. Korbutt include Vrije Universiteit Brussel & Stem Cell Network.
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Journal ArticleDOI
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
A. M. J. Shapiro,Jonathan R. T. Lakey,Edmond A. Ryan,Gregory S. Korbutt,Ellen L. Toth,Garth L. Warnock,Norman M. Kneteman,Ray V. Rajotte +7 more
TL;DR: The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.
Journal ArticleDOI
International Trial of the Edmonton Protocol for Islet Transplantation
A. M. James Shapiro,Camillo Ricordi,Bernhard J. Hering,Hugh Auchincloss,Robert Lindblad,R. Paul Robertson,Antonio Secchi,Mathias D. Brendel,Thierry Berney,Daniel C. Brennan,Enrico Cagliero,Rodolfo Alejandro,Edmond A. Ryan,Barbara S. Dimercurio,Philippe Morel,Kenneth S. Polonsky,Jo Anna Reems,Reinhard G. Bretzel,Federico Bertuzzi,Tatiana Froud,Raja Kandaswamy,David E.R. Sutherland,George S. Eisenbarth,Miriam Segal,Jutta K. Preiksaitis,Gregory S. Korbutt,Franca B. Barton,Lisa Viviano,Vicki Seyfert-Margolis,Jeffrey A. Bluestone,Jonathan R. T. Lakey +30 more
TL;DR: Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
Journal ArticleDOI
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Edmond A. Ryan,Jonathan R. T. Lakey,Ray V. Rajotte,Gregory S. Korbutt,Tatsuya Kin,Sharleen Imes,Alex Rabinovitch,John F. Elliott,David L. Bigam,Norman M. Kneteman,Garth L. Warnock,Ingrid Larsen,A. M. J. Shapiro +12 more
TL;DR: Islet transplantation has successfully corrected labile type 1 diabetes and problems with hypoglycemia, and the results show persistent insulin secretion, which is consistent with good glycemic control.
Journal ArticleDOI
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Edmond A. Ryan,Jonathan R. T. Lakey,Breay W. Paty,Sharleen Imes,Gregory S. Korbutt,Norman M. Kneteman,David L. Bigam,Ray V. Rajotte,A. M. James Shapiro +8 more
TL;DR: The results indicate that prolonged insulin independence can be achieved after islet transplantation, and there are some risks associated acutely with the procedure, and hypercholesterolemia and hypertension are treatable concerns on longer-term follow-up.
Journal ArticleDOI
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
Raewyn M. Seaberg,Simon R. Smukler,Timothy J. Kieffer,Grigori Enikolopov,Zeenat Asghar,Michael B. Wheeler,Gregory S. Korbutt,Derek van der Kooy +7 more
TL;DR: The clonal identification of multipotent precursor cells from the adult mouse pancreas is reported, which represent a previously unidentified adult intrinsic pancreatic precursor population and are a promising candidate for cell-based therapeutic strategies.