G
Griffin Haas
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 6
Citations - 208
Griffin Haas is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Betacoronavirus & Gene. The author has an hindex of 5, co-authored 5 publications receiving 90 citations.
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Journal ArticleDOI
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants
Satoshi Ikegame,Mohammed N. A. Siddiquey,Chuan-Tien Hung,Griffin Haas,Luca Brambilla,Kasopefoluwa Y. Oguntuyo,Shreyas Kowdle,Hsin-Ping Chiu,Christian S. Stevens,Ariel Esteban Vilardo,Alexis Edelstein,Claudia Perandones,Jeremy P. Kamil,Benhur Lee +13 more
TL;DR: In this paper, the authors characterize the neutralizing activity of post-Sputnik V vaccination sera against the ensemble of S mutations present in alpha (B.1.7) and beta (B1.351) VOCs, showing the latter to exhibit resistance to neutralization in vitro.
Journal ArticleDOI
Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.
Kasopefoluwa Y. Oguntuyo,Christian S. Stevens,Chuan Tien Hung,Satoshi Ikegame,Joshua A. Acklin,Shreyas Kowdle,Jillian C. Carmichael,Hsin-Ping Chiu,Kristopher D. Azarm,Griffin Haas,Fatima Amanat,Jéromine Klingler,Jéromine Klingler,Ian Baine,Suzanne Arinsburg,Juan C. Bandres,Juan C. Bandres,Mohammed N. A. Siddiquey,Robert M Schilke,Matthew D. Woolard,Hongbo Zhang,Andrew J. Duty,Thomas Kraus,Thomas M. Moran,Domenico Tortorella,Jean K. Lim,Andrea V. Gamarnik,Catarina E. Hioe,Catarina E. Hioe,Susan Zolla-Pazner,Stanimir S. Ivanov,Jeremy P. Kamil,Florian Krammer,Benhur Lee +33 more
TL;DR: The CoV2pp-VNA as mentioned in this paper is based on vesicular stomatitis virus bearing the Renilla luciferase gene in place of its G glycoprotein (VSVΔG), which can be robustly produced at scale and generate accurate neutralizing titers within 18 h postinfection.
Posted ContentDOI
Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera.
Kasopefoluwa Y. Oguntuyo,Christian S. Stevens,Chuan Tien Hung,Satoshi Ikegame,Joshua A. Acklin,Shreyas Kowdle,Jillian C. Carmichael,Hsin-Ping Chiu,Kristopher D. Azarm,Griffin Haas,Fatima Amanat,Jéromine Klingler,Jéromine Klingler,Ian Baine,Suzanne Arinsburg,Juan C. Bandres,Juan C. Bandres,Mohammed N. A. Siddiquey,Robert M Schilke,Matthew D. Woolard,Hongbo Zhang,Andrew J. Duty,Thomas Kraus,Thomas M. Moran,Domenico Tortorella,Jean K. Lim,Andrea V. Gamarnik,Catarina E. Hioe,Catarina E. Hioe,Susan Zolla-Pazner,Stanimir S. Ivanov,Jeremy P. Kamil,Florian Krammer,Benhur Lee +33 more
TL;DR: A standardized VNA using VSVdeltaG based CoV-2-S pseudotyped particles (CoV2pp) that can be robustly produced at scale and showed a strong positive correlation with CoV1-S ELISA and live virus neutralizations in a validated set of patient sera is developed.
Posted ContentDOI
Qualitatively distinct modes of Sputnik V vaccine-neutralization escape by SARS-CoV-2 Spike variants
Satoshi Ikegame,Mohammed N. A. Siddiquey,Chuan-Tien Hung,Griffin Haas,Luca Brambilla,Kasopefoluwa Y. Oguntuyo,Shreyas Kowdle,Ariel Esteban Vilardo,Alexis Edelstein,Claudia Perandones,Jeremy P. Kamil,Benhur Lee +11 more
TL;DR: The data suggest that control of emergent SARS-CoV-2 variants may benefit from updated vaccines, and that herd immunity may fail to eliminate the virus.
Posted ContentDOI
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.
Satoshi Ikegame,Mohammed N. A. Siddiquey,Chuan-Tien Hung,Griffin Haas,Luca Brambilla,Kasopefoluwa Y. Oguntuyo,Shreyas Kowdle,Ariel Esteban Vilardo,Alexis Edelstein,Claudia Perandones,Jeremy P. Kamil,Benhur Lee +11 more
TL;DR: In this paper, the authors characterize the biological consequences of the ensemble of Spike (S) mutations present in VOC lineages B.1.7 (501Y.V1) and B. 1.351 (501 Y.V2) using a replication-competent EGFP-reporter vesicular stomatitis virus (VSV) system.