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Guangxu Lan
Researcher at University of Chicago
Publications - 43
Citations - 3771
Guangxu Lan is an academic researcher from University of Chicago. The author has contributed to research in topics: Photodynamic therapy & Catalysis. The author has an hindex of 24, co-authored 37 publications receiving 2327 citations. Previous affiliations of Guangxu Lan include Peking University.
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Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy.
TL;DR: A nanoscale metal-organic framework, Fe-TBP, is reported as a novel nanophotosensitizer to overcome tumor hypoxia and sensitize effective PDT, priming non-inflamed tumors for cancer immunotherapy.
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Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy
Kuangda Lu,Chunbai He,Nining Guo,Christina Chan,Kaiyuan Ni,Guangxu Lan,Haidong Tang,Charles A. Pelizzari,Yang Xin Fu,Michael T. Spiotto,Ralph R. Weichselbaum,Wenbin Lin +11 more
TL;DR: By combining the advantages of local radiotherapy and systemic tumour rejection via synergistic X-ray-induced in situ vaccination and indoleamine 2,3-dioxygenase inhibition, nMOFs may overcome some of the limitations of checkpoint blockade in cancer treatment.
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Nanoscale Metal-Organic Frameworks for Phototherapy of Cancer.
TL;DR: This review summarizes recent advances on using nMOFs as nanoparticle PSs for applications in PDT and PTT and highlights the importance of efficient and selective delivery of PSs to the diseased tissues.
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Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy
Kaiyuan Ni,Guangxu Lan,Christina Chan,Bryan Quigley,Kuangda Lu,Theint Aung,Nining Guo,Patrick J. La Riviere,Ralph R. Weichselbaum,Wenbin Lin +9 more
TL;DR: The design of two porous Hf-based nanoscale metal-organic frameworks (nMOFs) as highly effective radioenhancers that significantly outperform HfO2, a clinically investigated radioenhancer in vitro and in vivo are reported.
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Titanium-Based Nanoscale Metal-Organic Framework for Type I Photodynamic Therapy.
Guangxu Lan,Kaiyuan Ni,Samuel S. Veroneau,Xuanyu Feng,Geoffrey T Nash,Taokun Luo,Ziwan Xu,Wenbin Lin +7 more
TL;DR: The design of a new nMOF, Ti-TBP, composed of Ti-oxo chain secondary building units (SBUs) and photosensitizing 5,10,15,20-tetra( p-benzoato)porphyrin (TBP) ligands, for hypoxia-tolerant type I PDT, which elicits superb anticancer efficacy with >98% tumor regression and 60% cure rate.