Author
Guangzhong. Wu
Bio: Guangzhong. Wu is an academic researcher from University of Delaware. The author has contributed to research in topics: Alkyne & Metallacycle. The author has an hindex of 6, co-authored 11 publications receiving 417 citations.
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TL;DR: The palladium-catalyzed reaction of vinylic bromides with disubstituted acetylenes at 100°C in the presence of triethylamine produces penta- or hexa-substitized fulvenes in low to moderate yields as mentioned in this paper.
31 citations
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TL;DR: An external-oxidant-free process to access the isoquinolone motif via cross-coupling/cyclization of benzhydroxamic acid with alkynes is described, pointing out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover.
Abstract: An external-oxidant-free process to access the isoquinolone motif via cross-coupling/cyclization of benzhydroxamic acid with alkynes is described. The reaction features a regioselective cleavage of a C-H bond on the benzhydroxamic acid coupling partner as well as a regioselective alkyne insertion. Mechanistic studies point out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover.
677 citations
TL;DR: The oxidative synthesis of highly functionalized indoles from simple anilines and internal alkynes mediated by a rhodium(III) catalyst is described and good regioselectivity is obtained.
Abstract: The oxidative synthesis of highly functionalized indoles from simple anilines and internal alkynes mediated by a rhodium(III) catalyst is described. Good yields are obtained for a variety of aniline substrates, and good regioselectivity is obtained for the more sterically accessible position when meta-substituted anilines are used. Symmetrical and unsymmetrical alkynes react efficiently with high (>40:1) C2/C3 regioselectivity when aryl/alkyl substituted alkynes are used.
634 citations
576 citations