G
Gudmundur A. Hardarson
Researcher at deCODE genetics
Publications - 5
Citations - 2523
Gudmundur A. Hardarson is an academic researcher from deCODE genetics. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 5, co-authored 5 publications receiving 2375 citations.
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Journal ArticleDOI
Variants conferring risk of atrial fibrillation on chromosome 4q25
Daniel F. Gudbjartsson,David O. Arnar,Anna Helgadottir,Solveig Gretarsdottir,Hilma Holm,Asgeir Sigurdsson,Adalbjorg Jonasdottir,Adam Baker,Gudmar Thorleifsson,Kristleifur Kristjansson,Arnar Palsson,Thorarinn Blondal,Patrick Sulem,Valgerdur M Backman,Gudmundur A. Hardarson,Ebba Palsdottir,Agnar Helgason,Runa Sigurjonsdottir,Jon Th. Sverrisson,Konstantinos Kostulas,Maggie C.Y. Ng,Larry Baum,Wing-Yee So,Ka Sing Wong,Juliana C.N. Chan,Karen L. Furie,Steven M. Greenberg,Michelle Sale,Peter J. Kelly,Calum A. MacRae,Eric E. Smith,Jonathan Rosand,Jan Hillert,Ronald C.W. Ma,Patrick T. Ellinor,Gudmundur Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Journal ArticleDOI
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Gudmar Thorleifsson,Kristinn P. Magnusson,Patrick Sulem,G. Bragi Walters,Daniel F. Gudbjartsson,Hreinn Stefansson,Thorlakur Jonsson,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Gerdur Stefansdottir,Gisli Masson,Gudmundur A. Hardarson,H. Petursson,Arsaell Arnarsson,Mehdi Motallebipour,Ola Wallerman,Claes Wadelius,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Fridbert Jonasson,Kari Stefansson +21 more
TL;DR: Two nonsynonymous SNPs in exon 1 of the gene LOXL1 explain the association with glaucoma, and the data suggest that they confer risk of XFG mainly through exfoliation syndrome (XFS).
Journal ArticleDOI
A genetic risk factor for periodic limb movements in sleep
Hreinn Stefansson,David B. Rye,Andrew A. Hicks,H. Petursson,Andres Ingason,Thorgeir E. Thorgeirsson,Stefan T Palsson,Thordur Sigmundsson,Albert P. Sigurdsson,Ingibjorg Eiriksdottir,Emilia Soebech,Donald L. Bliwise,Joseph M. Beck,Ami Rosen,Salina P. Waddy,Lynn Marie Trotti,Alex Iranzo,Madhav Thambisetty,Gudmundur A. Hardarson,Kristleifur Kristjansson,Larus J. Gudmundsson,Unnur Thorsteinsdottir,Augustine Kong,Jeffrey R. Gulcher,Daniel F. Gudbjartsson,Kari Stefansson +25 more
TL;DR: The inverse correlation of the variant with iron stores is consistent with the suspected involvement of iron depletion in the pathogenesis of the disease and is associated with susceptibility to periodic limb movements in sleep.
Journal ArticleDOI
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
Patrick Sulem,Daniel F. Gudbjartsson,Thorunn Rafnar,Hilma Holm,Hilma Holm,Elinborg J Olafsdottir,Gudridur H Olafsdottir,Thorvaldur Jonsson,Peter Alexandersen,Bjarke Feenstra,Heather A. Boyd,Katja K.H. Aben,André L. M. Verbeek,Nel Roeleveld,Aslaug Jonasdottir,Unnur Styrkarsdottir,Valgerdur Steinthorsdottir,Ari Karason,Simon N. Stacey,Julius Gudmundsson,Margret Jakobsdottir,Gudmar Thorleifsson,Gudmundur A. Hardarson,Jeffrey R. Gulcher,Augustine Kong,Lambertus A. Kiemeney,Mads Melbye,Claus Christiansen,Laufey Tryggvadottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +32 more
TL;DR: A genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM and 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM.
Journal ArticleDOI
Sequence variants in the RNF212 gene associate with genome-wide recombination rate.
Augustine Kong,Gudmar Thorleifsson,Hreinn Stefansson,Gisli Masson,Agnar Helgason,Daniel F. Gudbjartsson,Gudrun M. Jonsdottir,Sigurjon A. Gudjonsson,Sverrir T. Sverrisson,Theodora Thorlacius,Aslaug Jonasdottir,Gudmundur A. Hardarson,Stefan T Palsson,Michael L. Frigge,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Kari Stefansson +16 more
TL;DR: It is noteworthy that the haplotype formed by two single-nucleotide polymorphisms associated with the highest recombinations in males is associated with a low recombination rate in females, which means that if the frequency of the haplotypes changes, the average recombinations will increase for one sex and decrease for the other, but the sex-averaged recombination rates of the population can stay relatively constant.