Guido Kroemer

TL;DR: Results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC, in line with a general role of vitamin B6 in stress responses.

TL;DR: It is demonstrated that chemotherapy induces a rapid and prominent invasion of interleukin (IL)-17–producing γδ (Vγ4+ and Vγ6+) T lymphocytes (γδ T17 cells) that precedes the accumulation of Tc1 CTLs within the tumor bed, and plays a decisive role in chemotherapy-induced anticancer immune responses.

TL;DR: Results underscore the suitability of the high-throughput screening system described here for the identification of novel ICD inducers and pointed to septacidin, an antibiotic produced by Streptomyces fibriatus, as a novel putative inducer of ICD.

TL;DR: Clinical interest is being refocused on DC-based vaccines as combinatorial partners for T cell-targeting immunotherapies, reflecting the widespread immunosuppression within tumors.

TL;DR: Most of the preclinical data arguing in favor of OXPHOS inhibition have been obtained in xenograft models, in which human cancer cells are implanted in immunodeficient mice, and future studies should elaborate optimal treatment schedules and combination regimens that stimulate—or at least are compatible with—anticancer immune responses for long‐term tumor control.