G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs
Barbara S. Sixt,Robert J. Bastidas,Ryan Finethy,Ryan M Baxter,Victoria K. Carpenter,Guido Kroemer,Jörn Coers,Raphael H. Valdivia +7 more
TL;DR: CpoS-deficient strains are attenuated in their ability to propagate in cell culture and are cleared faster from the murine genital tract, highlighting the importance of CpoS for Chlamydia pathogenesis.
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Pro-necrotic molecules impact local immunosurveillance in human breast cancer
TL;DR: The idea that pro-necrotic signaling facilitates intratumoral immune responses in human breast cancer is supported.
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Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway
Ilio Vitale,Ilio Vitale,Ilio Vitale,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Sonia Vivet,Sonia Vivet,Sonia Vivet,Lisa Nanty,Lisa Nanty,Philippe Dessen,Laura Senovilla,Laura Senovilla,Laura Senovilla,Ken A. Olaussen,Ken A. Olaussen,Ken A. Olaussen,Vladimir Lazar,M. Prudhomme,Roy M. Golsteyn,Maria Castedo,Maria Castedo,Maria Castedo,Guido Kroemer,Guido Kroemer,Guido Kroemer +26 more
TL;DR: It is demonstrated that, in tetraploid tumor cells, the inhibition of Chk1 sequentially triggers aberrant mitosis, p53 activation and Puma/BBC3-dependent mitochondrial apoptosis.
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The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway
Thomas Roumier,H La Vieira,Maria Castedo,Karine F. Ferri,Patricia Boya,Karine Andreau,Sabine Druillennec,N Joza,Josef M. Penninger,Bernard P. Roques,Guido Kroemer +10 more
TL;DR: It appears that Vpr induces apoptosis through a caspase-independent mitochondrial pathway, and HIV-1-Env, which causes MMP through an indirect pathway, exhibit additive (but not synergic) cytotoxic effects.
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Mitochondrial apoptosis without VDAC
Lorenzo Galluzzi,Guido Kroemer +1 more
TL;DR: Voltage-dependent anion channels are thought to participate in mitochondrial-membrane permeabilization, an event that frequently delimits the frontier between cell life and death.