G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Palmitate induces apoptosis via a direct effect on mitochondria.
M. De Pablo,Santos A. Susin,Etienne Jacotot,Nathanael Larochette,Paola Costantini,Luigi Ravagnan,Naoufal Zamzami,Guido Kroemer +7 more
TL;DR: It is shown that the palmitate-induced dissipation of the mitochondrial transmembrane potential (ΔΨm), which precedes nuclear apoptosis, is not prevented by inhibitors of mRNA synthesis, protein synthesis, caspases, or pro-apoptotic ceramide signaling.
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Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways
Nadège Minois,Didac Carmona-Gutierrez,Maria A. Bauer,Patrick Rockenfeller,Tobias Eisenberg,Sebastian Brandhorst,Sebastian Brandhorst,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +10 more
TL;DR: It is established that the protective effects of Spd can be exerted through different pathways that depending on the oxidative stress scenario do or do not involve autophagy.
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Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects
Oliver Kepp,Laurie Menger,Erika Vacchelli,Sandy Adjemian,Isabelle Martins,Yuting Ma,Abdul Qader Sukkurwala,Mickaël Michaud,Lorenzo Galluzzi,Laurence Zitvogel,Guido Kroemer +10 more
TL;DR: Retrospective clinical data indicate that cardiac glycosides, notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy, and recent results suggest that CGs trigger the immunogenic demise of cancer cells.
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TP53 and MTOR crosstalk to regulate cellular senescence
TL;DR: The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet, but it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence.
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Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference
Nathalie Chaput,Nathalie Chaput,Stéphane de Botton,Michel Obeid,Michel Obeid,Lionel Apetoh,François Ghiringhelli,François Ghiringhelli,Theocharis Panaretakis,Theocharis Panaretakis,Caroline Flament,Caroline Flament,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer,Guido Kroemer,Guido Kroemer +17 more
TL;DR: The challenge will be to determine whether the exposure of calreticulin translocation on the tumour cell surface is linked to chemotherapy-induced anti-tumour immune responses and therapeutic efficacy in human cancer.