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Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Nervous yeast: modeling neurotoxic cell death
TL;DR: Yeast models for several major classes of neurodegeneration, namely alpha-synucleinopathy, polyglutamine disorders, beta-amyloid diseases, tauopathies, and TDP-43 proteinopathies have been established, pointing to ways in which yeast might advance the mechanistic dissection of cell death pathways relevant for human neurodegenersation.
Journal ArticleDOI
ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis.
Sandra Cabrera,Álvaro F. Fernández,Guillermo Mariño,Alina Aguirre,María F. Suárez,Yaiza Español,José A. Vega,Rosaria Laurà,Antonio Fueyo,M. Soledad Fernández-García,José M.P. Freije,Guido Kroemer,Carlos López-Otín +12 more
TL;DR: It is proposed that atg4b-null mice are a suitable model for in vivo studies aimed at testing new therapeutic strategies for intestinal diseases associated with autophagy deficiency and described ATG4B as a novel protective protein in inflammatory colitis.
Journal ArticleDOI
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Valentina Sica,Valentina Sica,Isabelle Martins,Isabelle Martins,Jonathan Pol,Jonathan Pol,Friedemann Loos,Friedemann Loos,Maria Chiara Maiuri,Maria Chiara Maiuri,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Gerasimos Anagnostopoulos,Mireia Niso-Santano,Fernando Aranda,Ignacio Ramírez-Pardo,Justine Lallement,Jessica Denom,Erwan Boedec,Erwan Boedec,Erwan Boedec,Philip Gorwood,Nicolas Ramoz,Karine Clément,Véronique Pelloux,Alili Rohia,François Pattou,Violeta Raverdy,Robert Caiazzo,Raphaël G. P. Denis,Patricia Boya,Lorenzo Galluzzi,Frank Madeo,Stéphanie Migrenne-Li,Céline Cruciani-Guglielmacci,Nektarios Tavernarakis,Nektarios Tavernarakis,Carlos López-Otín,Carlos López-Otín,Christophe Magnan,Guido Kroemer +46 more
TL;DR: neutralization of ACBP enhanced autophagy, stimulated fatty acid oxidation, inhibited appetite, reduced weight gain in the context of a high-fat diet or leptin deficiency, and accelerated weight loss in response to dietary changes.
Book ChapterDOI
Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis
Josef M. Penninger,Guido Kroemer +1 more
TL;DR: This chapter focuses on the genetic and molecular mechanisms of T lymphocyte apoptosis and also deals with the various phases of apoptosis initiation, execution, and degradation of lymphocytes.
Journal ArticleDOI
Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens
Sylvain Ladoire,Kariman Chaba,Isabelle Martins,Abdul Qader Sukkurwala,Sandy Adjemian,Mickaël Michaud,Vichnou Poirier-Colame,Felipe Andreiuolo,Lorenzo Galluzzi,Eileen White,Mathias T. Rosenfeldt,Kevin M. Ryan,Laurence Zitvogel,Guido Kroemer +13 more
TL;DR: A validated immunohistochemical protocol for the detection of LC3 puncta in human formalin-fixed, paraffin-embedded cancer specimens that can also be applied to mouse tissues is described and it is surmised that this technique can be employed for retrospective or prospective studies involving large series of human tumor samples.