G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
Glycogen synthase kinase 3‐mediated voltage‐dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation
Cécile Martel,Maya Allouche,Davide Degli Esposti,Elena Fanelli,Céline Boursier,Céline Henry,Joël Chopineau,Joël Chopineau,Giuseppe Calamita,Guido Kroemer,Antoinette Lemoine,Catherine Brenner +11 more
TL;DR: Outdoor mitochondrial membrane permeability is altered and a posttranslational modification of voltage‐dependent anion channel (VDAC), a membrane channel and NADH oxidase, is identified as a cause of early mitochondrial dysfunction.
Journal ArticleDOI
Dietary spermidine for lowering high blood pressure
Tobias Eisenberg,Mahmoud Abdellatif,Andreas Zimmermann,Sabrina Schroeder,Tobias Pendl,Alexandra Harger,Slaven Stekovic,Julia Schipke,Christoph Magnes,Albrecht Schmidt,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Didac Carmona-Gutierrez,Federico Pietrocola,Thomas R. Pieber,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +25 more
TL;DR: The protective capacity of the natural autophagy inducer spermidine was tested in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease.
Journal ArticleDOI
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson's disease models
Sabrina Büttner,L Faes,Wieland Reichelt,Filomena Broeskamp,Lukas Habernig,Stefan Benke,Nikos Kourtis,Doris Ruli,Didac Carmona-Gutierrez,Tobias Eisenberg,Petra D'hooge,Ruben Ghillebert,Vanessa Franssens,Alexandra Harger,Thomas R. Pieber,P Freudenberger,Guido Kroemer,Stephan J. Sigrist,Joris Winderickx,Geert Callewaert,Nektarios Tavernarakis,Frank Madeo +21 more
TL;DR: The α synuclein-driven rise of cytosolic Ca2+ levels is pivotal for its cytotoxicity and requires PMR1, which prevents αSyn-induced loss of dopaminergic neurons in nematodes and flies.
Journal ArticleDOI
Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia
Maximilien Tailler,Laura Senovilla,Elodie Lainey,Sylvain Thepot,Didier Métivier,Marie Sebert,Véronique Baud,Véronique Baud,Véronique Baud,K Billot,K Billot,K Billot,Pierre Fenaux,Lorenzo Galluzzi,S. Boehrer,Guido Kroemer,Oliver Kepp +16 more
TL;DR: The results suggest that PZ and OUA may exhibit antileukemic effects by inducing the apoptotic demise of AML cells.
Journal ArticleDOI
Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome.
S. Boehrer,Lionel Adès,Nicolas Tajeddine,Nicolas Tajeddine,Nicolas Tajeddine,Wolf-Karsten Hofmann,S. Kriener,Gesine Bug,Oliver G. Ottmann,Martin Ruthardt,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,C Fouassier,Maximilien Tailler,Maximilien Tailler,Maximilien Tailler,Ken A. Olaussen,Ken A. Olaussen,Ken A. Olaussen,Claude Gardin,Virginie Eclache,S. de Botton,Sylvain Thepot,Pierre Fenaux,Guido Kroemer,Guido Kroemer,Guido Kroemer +27 more
TL;DR: The heterogeneity of the DDR response in MDS and AML is demonstrated and evidence for its selective suppression inAML is provided because of the uncoupling between activated ATM and inactive checkpoint kinases.