G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
The molecular archaeology of a mitochondrial death effector: AIF in Drosophila
Nicholas Joza,Kathleen A. Galindo,J. A. Pospisilik,Paule Bénit,Manu Rangachari,E. E. Kanitz,Y. Nakashima,G. Gregory Neely,Pierre Rustin,John M. Abrams,Guido Kroemer,Guido Kroemer,Josef M. Penninger +12 more
TL;DR: It is shown that Drosophila AIF is a mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function.
Journal ArticleDOI
Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
Giorgio Frega,Giorgio Frega,Giorgio Frega,Qi Wu,Qi Wu,Julie Le Naour,Julie Le Naour,Erika Vacchelli,Erika Vacchelli,Lorenzo Galluzzi,Guido Kroemer,Oliver Kepp,Oliver Kepp +12 more
TL;DR: Preclinical and clinical evidence recently collected are summarized to support the development of resiquimod and motolIMod and other TLR7/TLR8 agonists as anticancer agents.
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Abscopal but desirable: The contribution of immune responses to the efficacy of radiotherapy.
Guido Kroemer,Laurence Zitvogel +1 more
TL;DR: Intriguingly, radiotherapy does not only have local effects but may lead to the delayed regression of distant non-irradiated lesions, and these “abscopal” effects are mediated by the immune system.
Journal ArticleDOI
Structure-function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA.
A.-L. Pauleau,A.-L. Pauleau,A.-L. Pauleau,N. Larochette,N. Larochette,N. Larochette,Fabrizio Giordanetto,S. R. Scholz,S. R. Scholz,S. R. Scholz,D. Poncet,D. Poncet,D. Poncet,Naoufal Zamzami,Naoufal Zamzami,Naoufal Zamzami,Victor S. Goldmacher,Guido Kroemer,Guido Kroemer,Guido Kroemer +19 more
TL;DR: It is found that Δ131–147 vMIA mutant, which lacks both the Bax-binding function and cell-death suppression but has intact mitochondria-targeting capacity, is similar to vMia in its ability to disrupt the mitochondrial network and to disorganize the actin cytoskeleton.
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Clearance of apoptotic photoreceptors. Elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin αvβ3.
Toshio Hisatomi,Taiji Sakamoto,Koh Hei Sonoda,C. Tsutsumi,Hong Qiao,Hiroshi Enaida,Ichiro Yamanaka,Toshiaki Kubota,Tatsuro Ishibashi,Shinobu Kura,Santos A. Susin,Guido Kroemer +11 more
TL;DR: It is demonstrated that apoptotic photoreceptors are selectively eliminated from their physiological localization, the outer nuclear layer, to the subretinal space, and then phagocytosed by monocyte-derived macrophages.