G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Therapeutic modulation of autophagy: which disease comes first?
TL;DR: The induction and inhibition of autophagy may provide new strategies for intervening on major and specific diseases, respectively, and the scheme provides an overview on pathologies that might be targeted by the manipulation of Autophagy.
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Acetyl-coenzyme A: A metabolic master regulator of autophagy and longevity
Sabrina Schroeder,Tobias Pendl,Andreas Zimmermann,Tobias Eisenberg,Didac Carmona-Gutierrez,Christoph Ruckenstuhl,Guillermo Mariño,Federico Pietrocola,Alexandra Harger,Christoph Magnes,Frank Sinner,Thomas R. Pieber,Jörn Dengjel,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +15 more
TL;DR: Novo-cytosolic AcCoA is proposed to act as a conserved metabolic rheostat, linking the cellular metabolic state to the regulation of autophagy via effects on protein acetylation.
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A multiplicity of cell death pathways: Symposium on Apoptotic and Non‐Apoptotic Cell Death Pathways
Pierre Golstein,Guido Kroemer +1 more
TL;DR: The Keystone Symposium on Apoptotic and Non‐Apoptotic Cell Death Pathways took place between 15 and 20 April 2007, in Monterey, CA, USA, and was organized by J. Yuan, D. Bredesen and Z. Zakeri.
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Loss-of-function alleles of P2RX7 and TLR4 fail to affect the response to chemotherapy in non-small cell lung cancer.
Erika Vacchelli,Lorenzo Galluzzi,Vanessa Rousseau,Alice Rigoni,Antoine Tesniere,Nicolas F. Delahaye,Frédéric Schlemmer,Laurie Menger,Abdul Qader Sukkurwala,Sandy Adjemian,Isabelle Martins,Mickaël Michaud,Ariane Dunant,Oliver Kepp,Elisabeth Brambilla,Jean-Charles Soria,Laurence Zitvogel,Guido Kroemer +17 more
TL;DR: It is reported that loss-of-function TLR4 and P2RX7 alleles do not affect overall survival in non-small cell lung cancer (NSCLC) patients, irrespective of the administration and type of chemotherapy.
Journal ArticleDOI
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Ralf J. Braun,Cornelia Sommer,Christine Leibiger,Romina J.G. Gentier,Verónica I. Dumit,Katrin Paduch,Tobias Eisenberg,Lukas Habernig,Gert Trausinger,Christoph Magnes,Thomas R. Pieber,Thomas R. Pieber,Frank Sinner,Frank Sinner,Jörn Dengjel,Fred W. van Leeuwen,Guido Kroemer,Frank Madeo +17 more
TL;DR: It is shown that in brain regions of AD patients with neurofibrillary tangles UBB+1 co-exists with VMS1, the mitochondrion-specific component of the ubiquitin-proteasome system (UPS) and can be reversed by Cdc48/Vms1-mediated proteolysis.