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Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling.
Borong Zhou,Jiao Liu,Ling Zeng,Shan Zhu,Haichao Wang,Timothy R. Billiar,Guido Kroemer,Daniel J. Klionsky,Herbert J. Zeh,Jianxin Jiang,Daolin Tang,Daolin Tang,Rui Kang +12 more
TL;DR: The role of sequestosome-1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of innate immunity, in sepsis is investigated and it is found that lipopolysaccharide elicits gasdermin D-dependent pyroptosis to enable passive SQSTM 1 release from macrophages and monocytes.
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A long non-coding RNA links calreticulin-mediated immunogenic cell removal to RB1 transcription
Musahl As,Xing Huang,Xing Huang,Xing Huang,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Evgenia Ntini,Annalisa Marsico,Guido Kroemer,Oliver Kepp,Oliver Kepp,Oliver Kepp,Ulf Andersson Ørom +12 more
TL;DR: Co-transcription of ncRNA-RB1 and RB1 provides a positive link between the expression of the two tumor suppressors RB1 and the immune-relevant CALR protein, exemplifies disease-relevant co-regulation of two distinct gene products.
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Autophagy induction for the treatment of cancer
Federico Pietrocola,Jonathan Pol,Erika Vacchelli,Elisa E. Baracco,Sarah Levesque,Francesca Castoldi,Maria Chiara Maiuri,Frank Madeo,Guido Kroemer +8 more
TL;DR: It is found that immunosurveillance against transplantable, carcinogen-induced or genetically engineered cancers can be improved by pharmacologically inducing autophagy with caloric restriction mimetics, and this positive effect depends on autophile induction in cancer cells.
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On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2.
Allan Sauvat,Allan Sauvat,Fabiola Ciccosanti,Francesca Colavita,Martina Di Rienzo,Concetta Castilletti,Maria Rosaria Capobianchi,Oliver Kepp,Oliver Kepp,Laurence Zitvogel,Gian Maria Fimia,Mauro Piacentini,Guido Kroemer +12 more
TL;DR: A tentative classification of SARS-CoV-2 antivirals into specific (on- target) versus non-specific (off-target) agents based on their physicochemical characteristics is proposed.
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Molecular mechanisms of sulfasalazine‐induced T‐cell apoptosis
Susanne Liptay,Simone Fulda,Marta Schanbacher,Soizic Bourteele,Karine F. Ferri,Guido Kroemer,Guido Adler,Klaus Michael Debatin,Roland M. Schmid +8 more
TL;DR: The data suggest that sulfasalazine‐induced apoptosis of T‐lymphocytes is mediated by mitochondrio‐nuclear translocation of AIF and occurs in a caspase‐independent fashion, and might provide the molecular basis for the beneficial therapeutic effects of sulf asalazine in the treatment of chronic inflammatory diseases.