G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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The central executioners of apoptosis: caspases or mitochondria?
Douglas R. Green,Guido Kroemer +1 more
TL;DR: It is argued that caspases might have a dual function in the apoptotic process: first, as signal-transduction molecules that act as facultative inducers of mitochondrial membrane changes, and, second, as processing enzymes that orchestrate the apoptosis phenotype.
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Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Antonella Sistigu,Takahiro Yamazaki,Erika Vacchelli,Kariman Chaba,David Enot,Julien Adam,Ilio Vitale,Aicha Goubar,Elisa E. Baracco,Catarina Remédios,Laetitia Fend,Dalil Hannani,Laetitia Aymeric,Yuting Ma,Mireia Niso-Santano,Oliver Kepp,Joachim L. Schultze,Thomas Tüting,Filippo Belardelli,Laura Bracci,Valentina La Sorsa,Giovanna Ziccheddu,Paola Sestili,Francesca Urbani,Mauro Delorenzi,Magali Lacroix-Triki,Virginie Quidville,Rosa Conforti,Jean Philippe Spano,Lajos Pusztai,Vichnou Poirier-Colame,Suzette Delaloge,Frédérique Penault-Llorca,Sylvain Ladoire,Laurent Arnould,Joanna Cyrta,Marie Charlotte Dessoliers,Alexander M.M. Eggermont,Marco Bianchi,Mikael J. Pittet,Camilla Engblom,Christina Pfirschke,Xavier Préville,Gilles Uzé,Robert D. Schreiber,Melvyn T. Chow,Mark J. Smyth,Enrico Proietti,Fabrice Andre,Guido Kroemer,Laurence Zitvogel +50 more
TL;DR: The data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens, and it is surmised that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
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Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis
Eric Daugas,Santos A. Susin,Naoufal Zamzami,Karine F. Ferri,Theano Irinopoulou,Nathanael Larochette,Marie-Christine Prévost,Brian Leber,David W. Andrews,Josef M. Penninger,Guido Kroemer +10 more
TL;DR: Data are compatible with the hypothesis that AIF is a caspase‐independent mitochondrial death effector responsible for partial chromatinolysis, and in conditions of ATP depletion, AIF translocation correlates with the appearance of large‐scale DNA fragmentation.
Journal ArticleDOI
Two distinct pathways leading to nuclear apoptosis.
Santos A. Susin,Eric Daugas,Luigi Ravagnan,Kumiko Samejima,Naoufal Zamzami,Markus Loeffler,Paola Costantini,Karine F. Ferri,Theano Irinopoulou,Marie-Christine Prévost,Tak W. Mak,Josef M. Penninger,William C. Earnshaw,Guido Kroemer +13 more
TL;DR: Two redundant parallel pathways may lead to chromatin processing during apoptosis, including one which involves Apaf-1 and caspases, as well as CAD, and leads to oligonucleosomal DNA fragmentation and advanced chromatin condensation and the other which is caspase-independent.
Journal ArticleDOI
Caspase-independent cell death.
Guido Kroemer,Seamus J. Martin +1 more
TL;DR: The contribution of caspases to cell death, either as upstream signals or as downstream effectors contributing to apoptotic morphology, is explored, as well as alternative strategies for cell death inhibition.