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Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Depletion of endonuclease G selectively kills polyploid cells.
Sabrina Büttner,Didac Carmona-Gutierrez,Ilio Vitale,Maria Castedo,Doris Ruli,Tobias Eisenberg,Guido Kroemer,Frank Madeo +7 more
TL;DR: It is concluded that endonuclease G is important for the viability of polyploid mammalian and yeast cells.
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Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.
Mohamed Jemaà,Gwenola Manic,Gwendaline Lledo,Delphine Lissa,Christelle Reynes,Nathalie Morin,Frédéric Chibon,Antonella Sistigu,Maria Castedo,Ilio Vitale,Guido Kroemer,Ariane Abrieu +11 more
TL;DR: A novel strategy to preferentially kill tetraploid cells based on the abrogation of the spindle assembly checkpoint (SAC) via the targeting of TTK protein kinase is reported, suggesting that MPS1 inhibition could be used as a therapeutic strategy for targeting tetraPLoid cancer cells.
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Intricate Links between ER Stress and Apoptosis
TL;DR: Bax inhibitor-1 interacts with Bax, neutralizing its proapoptotic activity, and directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.
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Tyrosine kinase inhibitors for the treatment of acute myeloid leukemia: delineation of anti-leukemic mechanisms of action.
Elodie Lainey,Sylvain Thepot,Sylvain Thepot,Cyrielle Bouteloup,Cyrielle Bouteloup,Marie Sebert,Marie Sebert,Lionel Ades,Lionel Ades,Maximilien Tailler,Maximilien Tailler,Maximilien Tailler,Claude Gardin,Stéphane de Botton,André Baruchel,Pierre Fenaux,Guido Kroemer,Simone Boehrer,Simone Boehrer +18 more
TL;DR: A side-by-side comparison of the anti-leukemic efficacy of four different tyrosine kinase inhibitors in MDS and AML and the biological phenomena underlying these mechanisms are explored are explored.
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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Qi Wu,Ai-Ling Tian,Bei Li,Marion Leduc,Sabrina Forveille,Peter Hamley,Warren Galloway,Wei Xie,Peng Liu,Liwei Zhao,Shuai Zhang,Pan Hui,Frank Madeo,Yi Tu,Oliver Kepp,Guido Kroemer +15 more
TL;DR: In this article, a high-content/high-throughput screen on 65 000 distinct compounds on a robotized fluorescence microscopy platform was performed to identify novel autophagy inducers.