G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Journal ArticleDOI
Contribution of annexin A1 to anticancer immunosurveillance
Elisa Elena Baracco,Elisa Elena Baracco,Gautier Stoll,Gautier Stoll,Peter van Endert,Laurence Zitvogel,Erika Vacchelli,Erika Vacchelli,Guido Kroemer +8 more
TL;DR: It is shown that ANXA1-deficent cancer cells exhibit a defect in the exposure of calreticulin (CALR), which is an important “eat-me” signal, facilitating the phagocytic uptake of dead-cell antigens by DC.
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Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy
Yuting Ma,Takahiro Yamazaki,Heng Yang,Oliver Kepp,Lorenzo Galluzzi,Laurence Zitvogel,Mark J. Smyth,Guido Kroemer +7 more
TL;DR: It is shown that the administration of anthracyclines to mice bearing established neoplasms stimulates the intratumoral secretion of tumor necrosis factor α (TNFα), which implies that, in contrast to other cytokines, TNFα is not required to elicit therapeutic anticancer immune responses.
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Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
TL;DR: Analysis of non-mutually exclusive mechanisms may account for a defect in the execution or regulation of MMP and improve the understanding of the basic function of mitochondria in apoptosis and help elaborate new strategies to correct MMP failure from a therapeutic perspective.
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Crizotinib - a tyrosine kinase inhibitor that stimulates immunogenic cell death.
TL;DR: It is observed that high-dose crizotinib can induce immunogenic cell death (ICD) in cancer cells lacking ALK/ROS1 activation through off-target effects that require the inhibition of several other tyrosine kinases.
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Natural killer cell mediated immunosurveillance of pediatric neuroblastoma.
TL;DR: The contention that NK cells play a decisive role in the immunosurveillance of neuroblastoma is supported, with the obvious expectation that efforts should be undertaken to investigate NK cell functions in all major cancer types.