G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe
TL;DR: A cell type-specific modulation of Cdk1 might be taken advantage of for the therapeutic correction of pathogenic imbalances in apoptosis control.
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Apoptosis-inducing factor: vital and lethal.
TL;DR: Recent progress is discussed in the quest to understand the contribution of AIF to life and death.
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Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore
Nathanael Larochette,Didier Decaudin,Didier Decaudin,Etienne Jacotot,Catherine Brenner,Isabel Marzo,Santos A. Susin,Naoufal Zamzami,Zhihua Xie,John C. Reed,Guido Kroemer +10 more
TL;DR: Evidence is provided that arsenic compounds may act on mitochondria to induce apoptosis via a direct effect on the mitochondrial PT pore, and data suggest that arsenite can induce apoptotic via adirect effect onThe mitochondria of arsenite-induced nuclear apoptosis.
Journal Article
Bcl-2 and Bcl-XL Antagonize the Mitochondrial Dysfunction Preceding Nuclear Apoptosis Induced by Chemotherapeutic Agents
Didier Decaudin,Stephan Geley,Tamara Hirsch,Maria Castedo,Philippe Marchetti,Antonio Macho,Reinhard Kofler,Guido Kroemer +7 more
TL;DR: Delta psi m disruption seems to be an obligatory step of early (pre-nuclear) apoptosis, and delta psi m is stabilized by two members of the bcl-2 gene family conferring resistance to chemotherapy.
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Regulation of autophagy by the inositol trisphosphate receptor
Alfredo Criollo,Maria Chiara Maiuri,Maria Chiara Maiuri,Ezgi Tasdemir,Ilio Vitale,Aline Fiebig,David W. Andrews,Jordi Molgó,Jorge Díaz,Sergio Lavandero,Francis Harper,Gérard Pierron,D. Di Stefano,Rosario Rizzuto,Gyorgy Szabadkai,Guido Kroemer +15 more
TL;DR: It is shown that knockdown of the IP3 receptor (IP3R) with small interfering RNAs and pharmacological IP3R blockade is a strong stimulus for the induction of autophagy, and exerts a major role in the physiological control ofautophagy.