G
Guido Kroemer
Researcher at Institut Gustave Roussy
Publications - 1546
Citations - 294816
Guido Kroemer is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 236, co-authored 1404 publications receiving 246571 citations. Previous affiliations of Guido Kroemer include Karolinska Institutet & Spanish National Research Council.
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Quantitation of mitochondrial alterations associated with apoptosis.
TL;DR: Methods for the detection of alterations in the DeltaPsi(m), based on the incubation of cells with cationic lipophilic fluorochromes, are delineated, which can be taken advantage of to detect apoptosis at an early stage.
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To Die or Not to Die: That is the Autophagic Question
Lorenzo Galluzzi,Jose Miguel Vicencio,Oliver Kepp,Ezgi Tasdemir,Maria Chiara Maiuri,Guido Kroemer +5 more
TL;DR: A general outline of autophagy is presented followed by a detailed analysis of organelle-specific autophagic pathways and of their intimate connections with cell death.
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AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis.
Céline Candé,Nicola Vahsen,Ilektra Kouranti,Elise Schmitt,Eric Daugas,Chris Spahr,Jeremy Luban,Romano T. Kroemer,Fabrizio Giordanetto,Carmen Garrido,Josef M. Penninger,Guido Kroemer +11 more
TL;DR: It is found that AIF and CypA collaborate in chromatinolysis, and the AIF-dependent large-scale DNA fragmentation was less pronounced in CypA knockout cells as compared to controls.
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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.
Sandeep Gurbuxani,Elise Schmitt,Céline Candé,Arnaud Parcellier,Arlette Hammann,Eric Daugas,Ilektra Kouranti,Chris Spahr,Alena Pance,Guido Kroemer,Carmen Garrido +10 more
TL;DR: It is demonstrated that AIF inhibition by HSP70 involves cytosolic retention of AIF, and it appears that endogenous H SP70 protein levels are sufficiently elevated to modulate the lethal action of Aif.
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Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors
Sylvie Rusakiewicz,Michaela Semeraro,Matthieu Sarabi,Mélanie Desbois,Clara Locher,Rosa Mendez,Nadege Vimond,Ángel Concha,Federico Garrido,Nicolas Isambert,Loic Chaigneau,Valérie Le Brun-Ly,Patrice Dubreuil,Isabelle Cremer,Anne Caignard,Vichnou Poirier-Colame,Kariman Chaba,Caroline Flament,Niels Halama,Dirk Jäger,Alexander M.M. Eggermont,Sylvie Bonvalot,Frédéric Commo,Philippe Terrier,Paule Opolon,Jean-François Emile,Jean-Michel Coindre,Guido Kroemer,Nathalie Chaput,Axel Le Cesne,Jean-Yves Blay,Laurence Zitvogel +31 more
TL;DR: It is found that CD3(+) TIL were highly activated in GIST and were especially enriched in areas of the tumor that conserve class I MHC expression despite imatinib mesylate treatment, which encourages the prospective validation of immune biomarkers for optimal risk stratification of patients with GIST.