Guido Kroemer

TL;DR: HSP27 and HSP70 may participate in oncogenesis, as suggested by the fact that overexpression of heat shock proteins can increase the tumorigenic potential of tumor cells.

TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.

TL;DR: This work reports that extracellular KRASG12D is essential for pancreatic tumor-associated macrophage polarization and identifies it as a key mediator of cancer cell-macrophage communication, and provides a novel KRAS-targeted anticancer strategy.

TL;DR: Several mechanisms by which mitochondria can contribute to malignant transformation and tumor progression are discussed.

TL;DR: It is pointed out that the successful implementation of immunotherapy to BC management requires the optimization of current immunotherapeutic regimens and the identification of immunological biomarkers that enable improved risk stratification and the design of personalized, dynamic treatment plans.